Non-RhD alloimmunization in pregnancy: an updated review.

Sabrina Menes Ares, Luciano Marcondes Machado Nardozza, Edward Araujo Júnior, Eduardo Félix Martins Santana
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Abstract

RhD alloimmunization in pregnancy is still the main cause of hemolytic disease of the fetus and neonate (HDFN). Nevertheless, there are other antigens that may be associated with the occurrence of this phenomenon and that have been growing in proportion, given that current prevention strategies focus only on anti-RhD antibodies. Although not widespread, the screening and diagnostic management of the disease caused by these antibodies has recommendations in the literature. For this reason, the following review was carried out with the objective of listing the main red blood cell antigen groups described - such as Rh, ABO, Kell, MNS, Duffy, Kidd, among others - addressing the clinical importance of each one, prevalence in different countries, and recommended management when detecting such antibodies during pregnancy.

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妊娠期非RhD同种免疫:最新综述。
妊娠期 RhD 同种免疫仍然是导致胎儿和新生儿溶血病(HDFN)的主要原因。然而,鉴于目前的预防策略只关注抗RhD抗体,还有其他抗原可能与这种现象的发生有关,而且其比例也在不断增加。由这些抗体引起的疾病的筛查和诊断管理虽然并不普遍,但在文献中也有建议。因此,我们进行了以下综述,目的是列出所描述的主要红细胞抗原群(如 Rh、ABO、Kell、MNS、Duffy、Kidd 等),探讨每种抗原的临床重要性、在不同国家的流行率,以及在孕期检测到此类抗体时的建议处理方法。
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