Merging 2,3-butanedione and N-hydroxysuccinimide as visible-light-enabled hydrogen atom transfer catalysts for CC double bond cleavage of 2-cyanoaryl acrylamides toward the synthesis of 4-amino-2-quinolones†
Jun Huang, Fengting Zhu, Jinlian Wen, Jiali Xu, Jing-Mei Yuan and Wenqiang Chen
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引用次数: 0
Abstract
The CC double bond cleavage of 2-cyanoaryl acrylamides through merging 2,3-butanedione and N-hydroxysuccinimide as visible-light-enabled hydrogen atom transfer catalysts is effectively established for generating functionalized 4-amino-2-quinolones under metal-free and redox neutral conditions. Detailed mechanism studies indicate that the solvent 1,3-dioxolane offers the crucial 1,3-dioxolan-2-yl radical facilitated by the in situ formed H-atom abstracting species, and 2-alkenyl-1,3-dioxolane is probably another product in this photocatalytic protocol.
期刊介绍：
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.
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