Effects of Phloroglucinol on Embryo Transfer: A Systematic Review and Meta-Analysis.

IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Gynecologic and Obstetric Investigation Pub Date : 2024-01-01 Epub Date: 2024-05-20 DOI:10.1159/000539340
Rui Cai, Jinli Lin, Yao Liu, Linhao Zhang, Xueying Li
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引用次数: 0

Abstract

Introduction: Phloroglucinol may be able to improve embryo transfer outcomes. We aimed to systematically evaluate the effects of phloroglucinol on embryo transfer outcomes.

Methods: The databases searched were PubMed, Ovid MEDLINE, Web of Science, Wanfang, CQVIP, China National Knowledge Infrastructure, and ClinicalTrials.gov. The last search was on February 7, 2023. The included studies were written in English or Chinese. Randomized controlled trials and cohort studies aiming to assess the effect of phloroglucinol on embryo transfer outcomes were included. The studies reported at least one of the primary outcomes (biochemical pregnancy rate, clinical pregnancy rate, and live birth rate). The odds ratio (OR) and 95% confidence interval (CI) were calculated. A random-effects or fixed model was used where applicable to estimate the results.

Results: Seventeen articles reporting 5,953 cycles were included. Biochemical pregnancy rate (OR = 1.58, 95% CI = 1.20-2.08, I2 = 71%), clinical pregnancy rate (OR = 1.69, 95% CI = 1.35-2.10, I2 = 64%), and live birth rate (OR = 1.45, 95% CI = 1.23-1.71, I2 = 36%) were improved by phloroglucinol. Less miscarriage (OR = 0.46, 95% CI = 0.35-0.60, I2 = 0%), less ectopic pregnancy (OR = 0.45, 95% CI = 0.28-0.72, I2 = 0%), higher implantation rate (OR = 1.45, 95% CI = 1.24-1.71, I2 = 62%) but more multiple pregnancy rate (OR = 1.48, 95% CI = 1.13-1.94, I2 = 0%) were induced by phloroglucinol. Endometrial peristaltic waves were improved by phloroglucinol (OR = 22.87, 95% CI = 5.52-94.74, I2 = 72%).

Conclusion: Phloroglucinol may improve the outcomes of embryo transfer, including biochemical pregnancy, clinical pregnancy, and live birth rates. Further studies are warranted.

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氯葡萄糖醇对胚胎移植的影响:系统回顾和荟萃分析。
简介叶绿素可改善胚胎移植结果。我们的目的是系统评估氯羟吡啶对胚胎移植结果的影响:检索的数据库包括 PubMed、Ovid MEDLINE、Web of Science、万方、CQVIP、中国国家知识基础设施和 ClinicalTrials.gov。最后一次检索时间为 2023 年 2 月 7 日。所纳入的研究均以英文或中文撰写。纳入的研究包括旨在评估氯葡甲醇对胚胎移植结果影响的随机对照试验和队列研究。这些研究至少报告了一项主要结果(生化妊娠率、临床妊娠率和活产率)。计算了几率比(OR)和 95% 的置信区间(CI)。在适用的情况下,采用随机效应或固定模型来估计结果:结果:共纳入了 17 篇报道 5953 个周期的文章。生化妊娠率(OR=1.58,95% CI=1.20-2.08,I²=71%)、临床妊娠率(OR=1.69,95% CI=1.35-2.10,I²=64%)和活产率(OR=1.45,95% CI=1.23-1.71,I²=36%)均有所提高。氯葡甲醇可减少流产(OR=0.46,95% CI=0.35-0.60,I²= 0%),减少异位妊娠(OR=0.45,95% CI=0.28-0.72,I²= 0%),提高着床率(OR=1.45,95% CI=1.24-1.71,I²= 62%),但增加多胎妊娠率(OR=1.48,95% CI=1.13-1.94,I²= 0%)。结论:氯氟甘醇可改善子宫内膜蠕动波(OR=22.87,95% CI=5.52-94.74,I²=72%):结论:氯羟吡啶可改善胚胎移植的结果,包括生化妊娠、临床妊娠和活产率。有必要进行进一步研究。
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来源期刊
CiteScore
4.20
自引率
4.80%
发文量
44
审稿时长
6-12 weeks
期刊介绍: This journal covers the most active and promising areas of current research in gynecology and obstetrics. Invited, well-referenced reviews by noted experts keep readers in touch with the general framework and direction of international study. Original papers report selected experimental and clinical investigations in all fields related to gynecology, obstetrics and reproduction. Short communications are published to allow immediate discussion of new data. The international and interdisciplinary character of this periodical provides an avenue to less accessible sources and to worldwide research for investigators and practitioners.
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