Identification of N-pyrrolidino protonitazene in powders sold as heroin and associated with overdose clusters in Dublin and Cork, Ireland.

IF 2.6 3区医学 Q2 BIOCHEMICAL RESEARCH METHODS Drug Testing and Analysis Pub Date : 2024-05-20 DOI:10.1002/dta.3707

Sarah Killoran, Sinéad McNamara, Pierce Kavanagh, John O'Brien, Rodney Lakes

引用次数: 0

Abstract

Synthetic opioids have been associated globally with adverse effects in drug users. The nitazene group of drugs is a relatively new addition to the synthetic opioid class emerging in Europe in 2019. Some nitazenes have been shown to be more potent than fentanyl. Overdose clusters in heroin users in Dublin (57 cases) and Cork (20 cases), Ireland, in November and December 2023, respectively, prompted a rapid response from a number of Irish laboratories to identify the substance(s) of concern. Light brown (tan) powders were obtained from cases associated with overdoses, and the results from these analyses by collaboration of four laboratories are reported here. The samples were found to contain N-pyrrolidino protonitazene (protonitazepyne), caffeine, paracetamol, benzoic acid and mannitol.

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在作为海洛因出售的粉末中鉴定出 N-吡咯烷基质子氮烯，这些粉末与爱尔兰都柏林和科克的用药过量集群有关。

合成类阿片在全球范围内都与吸毒者的不良反应有关。硝氮类药物是 2019 年在欧洲出现的合成类阿片中相对较新的一类。一些硝氮类药物已被证明比芬太尼更强。2023 年 11 月和 12 月，爱尔兰都柏林（57 例）和科克（20 例）分别发生海洛因吸食者用药过量集群事件，促使爱尔兰多家实验室迅速采取应对措施，以确定相关物质。从与用药过量有关的病例中获得了浅棕色（棕褐色）粉末，本文报告了四家实验室合作进行分析的结果。这些样品中含有 N-吡咯烷基原硝唑（原硝唑炔）、咖啡因、扑热息痛、苯甲酸和甘露醇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Testing and Analysis BIOCHEMICAL RESEARCH METHODS-CHEMISTRY, ANALYTICAL

CiteScore

5.90

自引率

24.10%

发文量

191

审稿时长

2.3 months

期刊介绍： As the incidence of drugs escalates in 21st century living, their detection and analysis have become increasingly important. Sport, the workplace, crime investigation, homeland security, the pharmaceutical industry and the environment are just some of the high profile arenas in which analytical testing has provided an important investigative tool for uncovering the presence of extraneous substances. In addition to the usual publishing fare of primary research articles, case reports and letters, Drug Testing and Analysis offers a unique combination of; ‘How to’ material such as ‘Tutorials’ and ‘Reviews’, Speculative pieces (‘Commentaries’ and ‘Perspectives'', providing a broader scientific and social context to the aspects of analytical testing), ‘Annual banned substance reviews’ (delivering a critical evaluation of the methods used in the characterization of established and newly outlawed compounds). Rather than focus on the application of a single technique, Drug Testing and Analysis employs a unique multidisciplinary approach to the field of controversial compound determination. Papers discussing chromatography, mass spectrometry, immunological approaches, 1D/2D gel electrophoresis, to name just a few select methods, are welcomed where their application is related to any of the six key topics listed below.