Association of atrial mechanical dispersion with atrial fibrillation recurrence following catheter ablation: results of the ASTRA-AF pilot study.

IF 3.8 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Clinical Research in Cardiology Pub Date : 2025-01-01 Epub Date: 2024-05-21 DOI:10.1007/s00392-024-02435-0

Dorit Knappe, Julia Vogler, Jessica Weimann, Victor Banas, Sevenai Yildirim, Felix Memenga, Juliana Senftinger, Laura Keil, Djemail Ismaili, Moritz Nies, Andreas Rillig, Stephan Willems, Stefan Blankenberg, Paulus Kirchhof, Andreas Metzner, Christoph Sinning

{"title":"Association of atrial mechanical dispersion with atrial fibrillation recurrence following catheter ablation: results of the ASTRA-AF pilot study.","authors":"Dorit Knappe, Julia Vogler, Jessica Weimann, Victor Banas, Sevenai Yildirim, Felix Memenga, Juliana Senftinger, Laura Keil, Djemail Ismaili, Moritz Nies, Andreas Rillig, Stephan Willems, Stefan Blankenberg, Paulus Kirchhof, Andreas Metzner, Christoph Sinning","doi":"10.1007/s00392-024-02435-0","DOIUrl":null,"url":null,"abstract":"Aims: For patients with symptomatic drug-refractory atrial fibrillation (AF), catheter ablation to achieve rhythm control is an important therapeutic option. The atrial mechanical dispersion measured as standard deviation of the time to peak strain (SD-TPS) is associated with the risk of AF recurrence following catheter ablation.Methods: The study cohort prospectively enrolled n = 132 consecutive patients with paroxysmal (n = 88) or persistent AF (n = 44) presenting for de novo pulmonary vein isolation (PVI) and followed for 1 year. We related left atrial (LA) volume, LA ejection fraction, SD-TPS, and global longitudinal strain of the left ventricle and clinical variables (sex, age, and type of AF) to AF recurrence.Results: Kaplan-Meier curves showed higher AF recurrence rate with an increase of SD-TPS with the calculated cut-off of 38.6 ms. Uni- and multivariable Cox regression analysis could show that SD-TPS had the highest relevance regarding AF recurrence with a HR of 1.05 (95% CI, 1.01; 1.09, p = 0.01) and HR of 1.05 (95% CI, 1.01; 1.09, p = 0.02) per 10 ms increase. In the additional analyses for the model including the clinical variables age, sex, and type of AF with paroxysmal or persisting AF, SD-TPS did only show a trend and after adjusting for covariates, SD-TPS showed a HR of 1.04 (95% CI, 0.99; 1.09, p = 0.09) per 10 ms increase.Conclusion: Atrial mechanical dispersion was associated with recurrent AF.","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":"103-111"},"PeriodicalIF":3.8000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11772373/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Research in Cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00392-024-02435-0","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/21 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Aims: For patients with symptomatic drug-refractory atrial fibrillation (AF), catheter ablation to achieve rhythm control is an important therapeutic option. The atrial mechanical dispersion measured as standard deviation of the time to peak strain (SD-TPS) is associated with the risk of AF recurrence following catheter ablation.

Methods: The study cohort prospectively enrolled n = 132 consecutive patients with paroxysmal (n = 88) or persistent AF (n = 44) presenting for de novo pulmonary vein isolation (PVI) and followed for 1 year. We related left atrial (LA) volume, LA ejection fraction, SD-TPS, and global longitudinal strain of the left ventricle and clinical variables (sex, age, and type of AF) to AF recurrence.

Results: Kaplan-Meier curves showed higher AF recurrence rate with an increase of SD-TPS with the calculated cut-off of 38.6 ms. Uni- and multivariable Cox regression analysis could show that SD-TPS had the highest relevance regarding AF recurrence with a HR of 1.05 (95% CI, 1.01; 1.09, p = 0.01) and HR of 1.05 (95% CI, 1.01; 1.09, p = 0.02) per 10 ms increase. In the additional analyses for the model including the clinical variables age, sex, and type of AF with paroxysmal or persisting AF, SD-TPS did only show a trend and after adjusting for covariates, SD-TPS showed a HR of 1.04 (95% CI, 0.99; 1.09, p = 0.09) per 10 ms increase.

Conclusion: Atrial mechanical dispersion was associated with recurrent AF.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

心房机械弥散与导管消融术后心房颤动复发的关系：ASTRA-AF 试验研究的结果。

目的：对于有症状的药物难治性心房颤动（房颤）患者来说，通过导管消融来控制心律是一种重要的治疗方法。以峰值应变时间标准差（SD-TPS）测量的心房机械离散度与导管消融术后房颤复发的风险有关：研究队列前瞻性地纳入了 n = 132 例连续的阵发性房颤（n = 88 例）或持续性房颤（n = 44 例）患者，这些患者接受了新的肺静脉隔离术（PVI），并随访了 1 年。我们将左心房（LA）容积、LA射血分数、SD-TPS和左心室整体纵向应变以及临床变量（性别、年龄和房颤类型）与房颤复发联系起来：Kaplan-Meier曲线显示，SD-TPS越高，房颤复发率越高，计算的临界值为38.6毫秒。单变量和多变量 Cox 回归分析表明，SD-TPS 与房颤复发的相关性最高，每增加 10 毫秒，HR 为 1.05（95% CI，1.01；1.09，p = 0.01）；每增加 10 毫秒，HR 为 1.05（95% CI，1.01；1.09，p = 0.02）。在包括临床变量年龄、性别和阵发性或持续性房颤类型的模型附加分析中，SD-TPS仅显示出一种趋势，在调整协变量后，SD-TPS每增加10毫秒的HR为1.04 (95% CI, 0.99; 1.09, p = 0.09)：结论：心房机械弥散与复发性房颤有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Clinical Research in Cardiology 医学-心血管系统

CiteScore

11.40

自引率

4.00%

发文量

140

审稿时长

4-8 weeks

期刊介绍： Clinical Research in Cardiology is an international journal for clinical cardiovascular research. It provides a forum for original and review articles as well as critical perspective articles. Articles are only accepted if they meet stringent scientific standards and have undergone peer review. The journal regularly receives articles from the field of clinical cardiology, angiology, as well as heart and vascular surgery. As the official journal of the German Cardiac Society, it gives a current and competent survey on the diagnosis and therapy of heart and vascular diseases.