COVID-19 therapeutics.

IF 19 1区 医学 Q1 MICROBIOLOGY Clinical Microbiology Reviews Pub Date : 2024-06-13 Epub Date: 2024-05-21 DOI:10.1128/cmr.00119-23
Daniele Focosi, Massimo Franchini, Fabrizio Maggi, Shmuel Shoham
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Abstract

SUMMARYSince the emergence of COVID-19 in 2020, an unprecedented range of therapeutic options has been studied and deployed. Healthcare providers have multiple treatment approaches to choose from, but efficacy of those approaches often remains controversial or compromised by viral evolution. Uncertainties still persist regarding the best therapies for high-risk patients, and the drug pipeline is suffering fatigue and shortage of funding. In this article, we review the antiviral activity, mechanism of action, pharmacokinetics, and safety of COVID-19 antiviral therapies. Additionally, we summarize the evidence from randomized controlled trials on efficacy and safety of the various COVID-19 antivirals and discuss unmet needs which should be addressed.

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COVID-19 疗法。
摘要自 2020 年出现 COVID-19 病毒以来,人们研究并采用了一系列前所未有的治疗方案。医疗服务提供者有多种治疗方法可供选择,但这些方法的疗效往往仍存在争议,或因病毒演变而受到影响。对于高危患者的最佳治疗方法仍存在不确定性,而药物管线也正处于疲劳期和资金短缺期。在本文中,我们回顾了 COVID-19 抗病毒疗法的抗病毒活性、作用机制、药代动力学和安全性。此外,我们还总结了有关各种 COVID-19 抗病毒药物疗效和安全性的随机对照试验证据,并讨论了应满足的未满足需求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical Microbiology Reviews
Clinical Microbiology Reviews 医学-微生物学
CiteScore
54.20
自引率
0.50%
发文量
38
期刊介绍: Clinical Microbiology Reviews (CMR) is a journal that primarily focuses on clinical microbiology and immunology.It aims to provide readers with up-to-date information on the latest developments in these fields.CMR also presents the current state of knowledge in clinical microbiology and immunology.Additionally, the journal offers balanced and thought-provoking perspectives on controversial issues in these areas.
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