Inflammation and Myocardial Blood Flow in Cardiac Sarcoidosis.

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Current Cardiology Reports Pub Date : 2024-07-01 Epub Date: 2024-05-22 DOI:10.1007/s11886-024-02070-1

Ashwin Singh Parihar, Ines Valenta, Salwa Mikhail, Alessio Imperiale, Thomas H Schindler

{"title":"Inflammation and Myocardial Blood Flow in Cardiac Sarcoidosis.","authors":"Ashwin Singh Parihar, Ines Valenta, Salwa Mikhail, Alessio Imperiale, Thomas H Schindler","doi":"10.1007/s11886-024-02070-1","DOIUrl":null,"url":null,"abstract":"Purpose of the review: Cardiac involvement in systemic sarcoidosis or isolated cardiac sarcoidosis plays a pivotal role in the clinical manifestation and prognostication. Active-inflammatory cardiac sarcoidosis is associated with a regional impairment of coronary microvascular function that may confer further detrimental effects on myocardial function needing further characterization.Recent findings: Clinical investigations with cardiac positron emission tomography/computed tomography in conjunction with 18F-fluorodeoxyglucose to determine myocardial inflammation and 13N-ammonia to quantify myocardial blood flow (MBF) in patients with known or suspected cardiac sarcoidosis outlined that sarcoidosis-induced myocardial inflammation was associated with adverse effects on corresponding regional coronary microvascular function. Notably, immune-suppressive treatment caused reductions in myocardial inflammation were paralleled by improvements of coronary microvascular dysfunction outlining direct adverse effect of inflammation on coronary arteriolar function. This review summarizes contributions of cardiac PET imaging in the identification and characterization of active-inflammatory cardiac sarcoidosis, its effect on coronary microvascular function, treatment responses, and prognostic implications.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":" ","pages":"717-722"},"PeriodicalIF":3.3000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Cardiology Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11886-024-02070-1","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/22 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of the review: Cardiac involvement in systemic sarcoidosis or isolated cardiac sarcoidosis plays a pivotal role in the clinical manifestation and prognostication. Active-inflammatory cardiac sarcoidosis is associated with a regional impairment of coronary microvascular function that may confer further detrimental effects on myocardial function needing further characterization.

Recent findings: Clinical investigations with cardiac positron emission tomography/computed tomography in conjunction with ¹⁸F-fluorodeoxyglucose to determine myocardial inflammation and ¹³N-ammonia to quantify myocardial blood flow (MBF) in patients with known or suspected cardiac sarcoidosis outlined that sarcoidosis-induced myocardial inflammation was associated with adverse effects on corresponding regional coronary microvascular function. Notably, immune-suppressive treatment caused reductions in myocardial inflammation were paralleled by improvements of coronary microvascular dysfunction outlining direct adverse effect of inflammation on coronary arteriolar function. This review summarizes contributions of cardiac PET imaging in the identification and characterization of active-inflammatory cardiac sarcoidosis, its effect on coronary microvascular function, treatment responses, and prognostic implications.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

心脏肉样瘤病的炎症和心肌血流

综述的目的：系统性肉样瘤病或孤立性心脏肉样瘤病的心脏受累在临床表现和预后中起着关键作用。活动性炎症性心脏肉样瘤病与冠状微血管功能的区域性损害有关，可能会对心肌功能造成进一步的不利影响，需要进一步定性：临床研究发现，在已知或疑似患有心脏肉样瘤病的患者中，心脏正电子发射断层扫描/计算机断层扫描与 18F- 氟脱氧葡萄糖结合使用，可确定心肌炎症情况，与 13N- 氨结合使用，可量化心肌血流量（MBF）。值得注意的是，免疫抑制治疗导致心肌炎症减轻的同时，冠状动脉微血管功能障碍也得到了改善，这说明炎症对冠状动脉功能有直接的不利影响。这篇综述总结了心脏 PET 成像在识别和描述活动性炎症性心脏肉样瘤病、其对冠状动脉微血管功能的影响、治疗反应和预后影响方面的贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Current Cardiology Reports CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

6.20

自引率

2.70%

发文量

209

期刊介绍： The aim of this journal is to provide timely perspectives from experts on current advances in cardiovascular medicine. We also seek to provide reviews that highlight the most important recently published papers selected from the wealth of available cardiovascular literature. We accomplish this aim by appointing key authorities in major subject areas across the discipline. Section editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.