Peripapillary Retinoschisis in Glaucoma: A Systematic Review.

IF 2 4区 医学 Q2 OPHTHALMOLOGY Journal of Glaucoma Pub Date : 2024-12-01 Epub Date: 2024-05-22 DOI:10.1097/IJG.0000000000002437
Maria Carolina Almeida, Margarida Ribeiro, João Barbosa-Breda
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Abstract

Prcis: Peripapillary retinoschisis (PPRS) may bias optical coherence tomography's (OCT) monitoring of glaucoma progression. Its impact on glaucoma still remains uncertain. Only 2 out of the 10 included studies illustrated a correlation between PPRS and glaucoma progression.

Objectives: The frequent use of OCT increased the detection of PPRS, which poses challenges in the follow-up of patients with glaucoma. This systematic review aims to summarize the literature regarding PPRS in glaucoma, exploring its prevalence, impact on disease, and clinical management implications.

Methods: We searched PubMed, Embase, Web of Science, and Scopus with tailored search queries for each platform. All studies had to report PPRS in patients with glaucoma. Exclusion criteria included studies with <10 eyes, studies focusing on schisis outside the disc area, with concomitant retinal or optic nerve lesions, with animals, reviews, studies written in non-English language, and congress abstracts.

Results: Ten studies were included, of which 7 were case-control, one was a cohort study, and 2 were case series.Six studies showed that PPRS often overlapped preexisting retinal nerve fiber layer defects. One study reported that the de novo development of PPRS was more frequent in eyes with glaucoma progression than in eyes without progression.Visual field findings were inconsistent, with just one study (out of 6) showing that patients with glaucoma with PPRS experienced faster visual field deterioration than those without it. Overall, solely 2 studies (out of 7) associated PPRS with faster glaucoma progression.

Conclusions: PPRS biases OCT analysis in glaucoma. Caution is needed against overestimation of retinal nerve fiber layer thickness when PPRS develops and misinterpretation of its resolution as rapid progression. PPRS' exact impact on glaucoma progression remains unclear.

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青光眼视网膜毛周炎:系统综述。
Prcis:毛细血管周围视网膜裂孔可能会影响光学相干断层扫描对青光眼进展的监测。其对青光眼的影响仍不确定。目的:光学相干断层扫描的频繁使用增加了对毛细血管周围视网膜裂孔的检测,这给青光眼患者的随访带来了挑战。本系统综述旨在总结有关青光眼视网膜毛细血管周围炎的文献,探讨其发病率、对疾病的影响以及对临床管理的意义:我们检索了 PubMed、Embase、Web of Science 和 Scopus,并为每个平台定制了搜索查询。所有研究都必须报告青光眼患者的毛细血管周围视网膜裂孔。排除标准包括:少于10只眼睛的研究、侧重于视盘区以外裂孔的研究、伴有视网膜或视神经病变的研究、动物研究、综述、以非英语撰写的研究以及大会摘要:六项研究显示,毛细血管周围视网膜裂孔常与原有的视网膜神经纤维层缺损重叠。六项研究显示,毛细血管周围视网膜裂孔常常与原有的视网膜神经纤维层缺损重叠。一项研究报告称,青光眼进展期患者比未进展期患者更容易出现毛细血管周围视网膜裂孔。视野研究结果不一致,仅有一项研究(共六项)显示,患有毛细血管周围视网膜裂孔的青光眼患者视野恶化速度快于未患有毛细血管周围视网膜裂孔的患者。总体而言,只有两项研究(共七项)将毛细血管周围视网膜脱离与青光眼进展加快联系在一起:结论:毛细血管周围视网膜裂孔会对青光眼的光学相干断层扫描分析产生偏差。当出现毛细血管周围视网膜裂孔时,需要注意不要过高估计视网膜神经纤维层的厚度,也不要将视网膜裂孔的消除误解为青光眼的快速进展。毛细血管周围视网膜脱离对青光眼进展的确切影响仍不清楚。
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来源期刊
Journal of Glaucoma
Journal of Glaucoma 医学-眼科学
CiteScore
4.20
自引率
10.00%
发文量
330
审稿时长
4-8 weeks
期刊介绍: The Journal of Glaucoma is a peer reviewed journal addressing the spectrum of issues affecting definition, diagnosis, and management of glaucoma and providing a forum for lively and stimulating discussion of clinical, scientific, and socioeconomic factors affecting care of glaucoma patients.
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