CLINICAL CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH SEVERE COVID-19 AND CIRRHOSIS OR LIVER TRANSPLANT IN A BRAZILIAN QUATERNARY CENTER.

Q2 Medicine Arquivos de Gastroenterologia Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI:10.1590/S0004-2803.24612023-145

Tulio L Correa, Mariana Sandoval Terra Campos Guelli, Ricardo Tavares de Carvalho

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Abstract

Background: Specific associations between liver cirrhosis and liver transplant with poorer outcomes in COVID-19 are still not completely clear.

Objective: We aimed to evaluate the clinical characteristics and outcomes of patients with severe COVID-19 and cirrhosis or liver transplant in Sao Paulo, Brazil.

Methods: A retrospective observational study was conducted in a quaternary hospital. Patients with COVID-19 and liver cirrhosis or liver transplant were selected. The clinical and demographic characteristics, as well as the outcomes, were assessed using electronic records.

Results: A total of 46 patients with COVID-19 and liver condition were included in the study. Patients with liver cirrhosis had significantly more endotracheal intubation and a higher relative risk of death than liver transplant recipients. Patients with higher MELD-Na scores had increased death rates and lower survival probability and survival time.

Conclusion: Patients with liver cirrhosis, especially those with higher MELD-Na scores, had poorer outcomes in COVID-19. Liver transplant recipients do not seem to be linked to poorer COVID-19 outcomes.

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巴西一家四级中心的重度Covid-19和肝硬化或肝移植患者的临床特征和治疗效果。

背景：在 COVID-19 中，肝硬化和肝移植与较差预后之间的具体关联仍不完全清楚：肝硬化和肝移植与 COVID-19 较差预后之间的具体关联仍不完全清楚：我们旨在评估巴西圣保罗严重 COVID-19 合并肝硬化或肝移植患者的临床特征和预后：在一家四级医院开展了一项回顾性观察研究。研究选择了 COVID-19 和肝硬化或肝移植患者。结果：共有46名COVID-19患者患有肝硬化或肝移植：研究共纳入了 46 名患有 COVID-19 和肝病的患者。与肝移植受者相比，肝硬化患者的气管插管次数明显增多，死亡的相对风险也更高。MELD-Na评分越高的患者死亡率越高，存活概率和存活时间越低：结论：肝硬化患者，尤其是 MELD-Na 评分较高的患者，在 COVID-19 中的预后较差。肝移植受者似乎与较差的 COVID-19 结果无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arquivos de Gastroenterologia Medicine-Gastroenterology

CiteScore

2.00

自引率

0.00%

发文量

109

审稿时长

9 weeks

期刊介绍： The journal Arquivos de Gastroenterologia (Archives of Gastroenterology), a quarterly journal, is the Official Publication of the Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia IBEPEGE (Brazilian Institute for Studies and Research in Gastroenterology), Colégio Brasileiro de Cirurgia Digestiva - CBCD (Brazilian College of Digestive Surgery) and of the Sociedade Brasileira de Motilidade Digestiva - SBMD (Brazilian Digestive Motility Society). It is dedicated to the publishing of scientific papers by national and foreign researchers who are in agreement with the aim of the journal as well as with its editorial policies.