Stephanie N Steinberg, Kelsey C Hewitt, Cady K Block
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引用次数: 0
Abstract
Objective: Neuroendocrine tumors (NETs) are neoplasms that primarily occur in the lungs, appendix, small intestine, pancreas, and rectum, and typically metastasize to the liver or lymph nodes. However, in rare cases NETs can originate in the central nervous system (CNS). Understanding primary CNS NET neuropsychological manifestations aids in recommendations for neurocognitive follow-up, treatment and lifestyle planning, and future research. Method: Given the dearth of neuropsychological research for CNS NETs, we present a case seen in a 43-year-old woman. Results: Initial and 8-month follow-up neuropsychological evaluations of the patient revealed a Major Neurocognitive Disorder where the pattern of findings was consistent with tumor location and additional treatment-related factors. Reliable change indices at her re-evaluation revealed declines in verbal and visual memory, with statistical, yet not clinical, improvements in different domains. Follow-up monitoring of comprehensive care continued to occur after neuropsychological evaluations. Conclusions: This case study assists in the characterization of initial and follow-up neuropsychological presentation of a primary CNS NET, where evaluations helped inform clinical care and functional recommendations. This case demonstrates the importance for neuropsychologists to have awareness of various conditions, even rare conditions, which can inform a systematic approach to research and clinical care with neuro-oncological populations.
目的:神经内分泌肿瘤(NET神经内分泌肿瘤(NET)是主要发生在肺、阑尾、小肠、胰腺和直肠的肿瘤,通常会转移到肝脏或淋巴结。不过,在极少数情况下,NET 也可能起源于中枢神经系统(CNS)。了解原发性中枢神经系统 NET 的神经心理学表现有助于为神经认知随访、治疗和生活方式规划以及未来研究提供建议。方法:鉴于对中枢神经系统 NET 神经心理学研究的缺乏,我们介绍了一例 43 岁女性的病例。研究结果对患者进行的初次和 8 个月的随访神经心理学评估显示,患者存在严重的神经认知障碍,其发现模式与肿瘤位置和其他治疗相关因素一致。在对她进行再次评估时,可靠的变化指数显示她的言语和视觉记忆能力有所下降,不同领域的数据均有所改善,但没有临床改善。神经心理评估后,继续对综合护理进行后续监测。结论:本病例研究有助于描述原发性中枢神经系统母细胞瘤的初始和随访神经心理学表现,评估结果有助于为临床治疗和功能建议提供依据。本病例表明,神经心理学家对各种疾病,甚至是罕见疾病的认识非常重要,这可以为神经肿瘤人群的研究和临床治疗提供系统的方法。
期刊介绍:
The Clinical Neuropsychologist (TCN) serves as the premier forum for (1) state-of-the-art clinically-relevant scientific research, (2) in-depth professional discussions of matters germane to evidence-based practice, and (3) clinical case studies in neuropsychology. Of particular interest are papers that can make definitive statements about a given topic (thereby having implications for the standards of clinical practice) and those with the potential to expand today’s clinical frontiers. Research on all age groups, and on both clinical and normal populations, is considered.