Willingness to use PrEP among PrEP naïve men who have sex with men: a meta-analysis.

IF 1.2 4区 医学 Q4 HEALTH POLICY & SERVICES Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2024-08-01 Epub Date: 2024-05-21 DOI:10.1080/09540121.2024.2354207
Swarnali Goswami, Taylor Gannon, Saara Nasruddin, Blake Mancuso, Minsoo Kang, John P Bentley, Kaustuv Bhattacharya, Marie Barnard
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Abstract

This study aimed to measure the pooled estimate of willingness to use HIV pre-exposure prophylaxis (PrEP) (WTUP) among PrEP-naïve United States (U.S.)-based men who have sex with men (MSM). PubMed, Embase, Web of Science, CINAHL, and PsycINFO were searched. The search strategy contained the keyword willingness and interest and the MeSH terms for HIV and PrEP. Articles were included if they were published between January 2005 and May 2022, reported quantitative data on WTUP among PrEP-naïve US-based MSM, and were available as full text in English. Meta-analysis was conducted to assess the pooled effect size of WTUP prevalence using a random-effects model, heterogeneity in the pooled estimate was assessed, and subgroup analyzes were conducted. Fifteen studies were included based on the inclusion and exclusion criteria. Meta-analysis revealed a pooled prevalence proportion for WTUP of 0.58 (95% CI 0.54-0.61) (or 58 out of 100) among PrEP-naïve MSM. High inter-study heterogeneity (Q = 548.10, df = 19, p < 0.01, I2 = 96.53, τ2 = 0.09) was observed. Age of the study sample and region where the data were collected significantly moderated the pooled WTUP estimate. Age-appropriate PrEP related messaging and a focus on HIV priority areas of the U.S. would be important strategies to improve WTUP among MSM in the U.S. moving forward.

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PrEP 新手中使用 PrEP 的意愿:一项荟萃分析。
本研究旨在衡量美国(U.S.)男男性行为者(MSM)中未接受过艾滋病暴露前预防(PrEP)治疗的人群使用艾滋病暴露前预防(PrEP)的意愿(WTUP)。对 PubMed、Embase、Web of Science、CINAHL 和 PsycINFO 进行了检索。检索策略包括关键词 "意愿和兴趣 "以及 MeSH 词语 "HIV "和 "PrEP"。纳入的文章必须发表于 2005 年 1 月至 2022 年 5 月之间,报告了 PrEP 尝试者中的美国 MSM 的 WTUP 定量数据,并有英文全文。采用随机效应模型进行 Meta 分析以评估 WTUP 流行率的集合效应大小,评估集合估计值的异质性,并进行亚组分析。根据纳入和排除标准,共纳入了 15 项研究。Meta 分析显示,在 PrEP 未接受治疗的 MSM 中,WTUP 的汇总流行率为 0.58(95% CI 0.54-0.61)(或 100 例中有 58 例)。研究间存在高度异质性(Q = 548.10, df = 19, p 2 = 96.53, τ2 = 0.09)。研究样本的年龄和数据收集地区在很大程度上影响了 WTUP 的汇总估计值。与年龄相适应的 PrEP 相关信息以及对美国 HIV 重点地区的关注将是改善美国 MSM WTUP 的重要策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.50
自引率
0.00%
发文量
172
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