Histopathological Study of Breast Cancer at the Oran University Hospital Center on a Population from Western Algeria.

Abstract

Breast cancer (BC) is the most common cancer among women worldwide and also in Algeria. Despite therapeutic progress, it remains a cancer with serious physical and psychological consequences.

Materials and methods: The objective of this study was to perform a histological analysis on 244 patients from the western Algerian population who were receiving treatment at the Oran University Hospital.

Results and discussion: The findings of our study indicates that women are more likely to be affected, with a predominance of tumors in the right breast (77%), we also found that (72%) of patients had a personal history risk of developing breast cancer. The majority of the cases that were examined were in the age range of 40 to 50. In addition, we noticed that unemployed and married women were the most affected, with (86% and 95%, respectively). Total of (63%) patients used contraceptives known to be endocrine disruptors and (68%) of cases were breast-feeding.Our results revealed that the most frequent histological type is the infiltrative ductal carcinoma (77%) followed by the ductal carcinoma in situ which is (13%), on the other hand the infiltrative lobular carcinoma presents a very low percentage (9%). The SBR II grade is the most dominant with (81%) followed by the SBRIII grade (18%) and no cases of SBR I grade were observed.

Conclusion: Breast cancer is one of the most complex and difficult to control diseases, especially in developing countries. Breast cancer screening remains a powerful way of improving early detection and survival rate. The Findings of our study demonstrate that histopathological analysis provides an important prognostic information and, if the grading protocol is followed consistently, reproducible results can be obtained for a favorable prognosis and management of breast cancer to reduce the burden of the disease.

Key words: Breast cancer, risk factor, histopathology, chemotherapy and radiotherapy.