Bismuth selenide nanoparticles enhance radiation sensitivity in colon cancer cells in-vitro

IF 2.3 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry and Biophysics Reports Pub Date : 2024-05-21 DOI:10.1016/j.bbrep.2024.101732

Hossein Khosravi , Hamed Manoochehri , Abbas Farmany , Alireza Khoshghadam , Hassan Rafieemehr , Rasool Azmoonfar

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Abstract

Background

Radiotherapy is one of the primary treatments for cancer, but it can cause damage to normal tissues and lead to side effects. The use of radiosensitizers can enhance the sensitivity of cancer cells to radiation, thereby reducing the amount of radiation required and minimizing damage to healthy tissues. Bismuth selenide nanoparticles (Bi2Se3 NPs) have been shown to have potential as radiosensitizers.

Materials and methods

In this study, we investigated the potential of Bi2Se3 NPs as a radiosensitizer in colon cancer cells (HCT-116) in vitro. The cells were treated with various concentrations of Bi2Se3 NPs and then exposed to ionizing radiation. The viability of the cells was assessed using the MTT assay, and the survival rate was evaluated.

Results

Our results showed that Bi2Se3 NPs significantly enhanced the sensitivity of colon cancer cells to ionizing radiation in a dose-dependent manner. The combination of Bi2Se3 NPs and radiation resulted in a significant decrease in cell viability and survival rate compared to radiation alone.

Conclusion

Bi2Se3 NPs have the potential to be used as a radiosensitizer in the treatment of colon cancer. The findings of this study suggest that combining Bi2Se3 NPs with radiation may enhance the effectiveness of radiotherapy and reduce the mortality rate associated with colon cancer. Further studies are needed to investigate the safety and efficacy of this approach in vivo.

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硒化铋纳米粒子提高结肠癌细胞对体外辐射的敏感性

背景放疗是治疗癌症的主要方法之一，但它会对正常组织造成损伤，并导致副作用。使用放射增敏剂可以提高癌细胞对辐射的敏感性，从而减少所需的辐射量，并将对健康组织的损害降至最低。硒化铋纳米粒子（Bi2Se3 NPs）已被证明具有作为放射增敏剂的潜力。材料和方法在这项研究中，我们在体外研究了 Bi2Se3 NPs 作为结肠癌细胞（HCT-116）放射增敏剂的潜力。细胞经不同浓度的 Bi2Se3 NPs 处理后暴露于电离辐射。结果表明，Bi2Se3 NPs 以剂量依赖的方式显著增强了结肠癌细胞对电离辐射的敏感性。结论 Bi2Se3 NPs 有潜力用作治疗结肠癌的放射增敏剂。本研究的结果表明，将 Bi2Se3 NPs 与放射线结合使用可提高放射治疗的效果，降低结肠癌的死亡率。还需要进一步研究这种方法在体内的安全性和有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.