New Opportunities for Electric Fields in Promoting Wound Healing: Collective Electrotaxis.

IF 5.8 3区医学 Q1 DERMATOLOGY Advances in wound care Pub Date : 2024-07-15 DOI:10.1089/wound.2024.0003

Yan Zhang, Shiwen Huang, Yifei Cao, Li Li, Jun Yang, Min Zhao

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Abstract

Significance: It has long been hypothesized that naturally occurring electric fields (EFs) aid wound healing by guiding cell migration. Consequently, the application of EFs has significant potential for promoting wound healing. However, the mechanisms underlying the cellular response to EFs remain unclear. Recent Advances: Although the directed migration of isolated single cells under EFs has been studied for decades, only recently has experimental evidence demonstrated the distinct collective migration of large sheets of keratinocytes and corneal epithelial cells in response to applied EFs. Accumulating evidence suggests that the emergent properties of cell groups in response to EF guidance offer new opportunities for EF-assisted directional migration. Critical Issues: In this review, we provide an overview of the field of collective electrotaxis, highlighting key advances made in recent years. We also discuss advanced engineering strategies utilized to manipulate collective electrotaxis. Future Directions: We outline a series of unanswered questions in this field and propose potential applications of collective electrotaxis in developing electrical stimulation technologies for wound healing.

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电场促进伤口愈合的新机遇：集体电疗。

意义重大：长期以来，人们一直假设自然产生的电场（EF）可通过引导细胞迁移来帮助伤口愈合。因此，应用电场促进伤口愈合具有巨大的潜力。然而，细胞对电场反应的基本机制仍不清楚。最新进展：虽然孤立的单细胞在电场作用下的定向迁移已被研究了几十年，但直到最近才有实验证据表明，大片角质形成细胞和角膜上皮细胞在电场作用下会发生明显的集体迁移。越来越多的证据表明，细胞群在EF引导下的新特性为EF辅助定向迁移提供了新的机会：在这篇综述中，我们概述了集体电迁移领域，重点介绍了近年来取得的主要进展。我们还讨论了用于操纵集体电共振的先进工程策略：未来方向：我们概述了该领域的一系列未解之谜，并提出了集体电共振在开发伤口愈合电刺激技术方面的潜在应用。

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来源期刊

Advances in wound care Medicine-Emergency Medicine

CiteScore

12.10

自引率

4.10%

发文量

期刊介绍： Advances in Wound Care rapidly shares research from bench to bedside, with wound care applications for burns, major trauma, blast injuries, surgery, and diabetic ulcers. The Journal provides a critical, peer-reviewed forum for the field of tissue injury and repair, with an emphasis on acute and chronic wounds. Advances in Wound Care explores novel research approaches and practices to deliver the latest scientific discoveries and developments. Advances in Wound Care coverage includes: Skin bioengineering, Skin and tissue regeneration, Acute, chronic, and complex wounds, Dressings, Anti-scar strategies, Inflammation, Burns and healing, Biofilm, Oxygen and angiogenesis, Critical limb ischemia, Military wound care, New devices and technologies.