The value of combined MRI, enhanced CT and ¹⁸F-FDG PET/CT in the diagnosis of recurrence and metastasis after surgery for ovarian cancer.

IF 2.8 3区医学 Q2 ONCOLOGY Clinical & Translational Oncology Pub Date : 2024-12-01 Epub Date: 2024-05-23 DOI:10.1007/s12094-024-03499-0

Yong Hong, Jianfeng Peng, Yanni Zeng, Xuewen Deng, Wanjun Xu, Juanting Wang

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Abstract

Objective: The purpose of this article was to investigate the value of combined MRI, enhanced CT and ¹⁸F-FDG PET/CT in the diagnosis of recurrence and metastasis after surgery for ovarian cancer.

Methods: Ninety-five ovarian cancer patients were selected as the study subjects, all of them underwent surgical treatment, and MRI, enhanced CT and ¹⁸F-FDG PET/CT were performed on all of them in the postoperative follow-up, and the pathological results after the second operation were used as the diagnostic "gold standard". The diagnostic value (sensitivity, specificity, accuracy, negative predictive value and positive predictive value) of the three examination methods alone or in combination for the diagnosis of postoperative recurrence and metastasis of ovarian cancer was compared, and the detection rate was calculated when the lesion was the unit of study, so as to compare the efficacy of the three methods in the diagnosis of postoperative recurrent metastatic lesions of ovarian cancer.

Results: The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of the combined group were higher than those of MRI and enhanced CT for recurrence and metastasis of ovarian cancer after surgery, and the specificity, accuracy and positive predictive value of the combined group were higher than those of the ¹⁸F-FDG PET/CT group, and those of the ¹⁸F-FDG PET/CT group were higher than those of the enhanced CT group (all P < 0.05). When the postoperative recurrent metastatic lesions of ovarian cancer were used as the study unit, the detection rate of lesions in the combined group was higher than that of the three examinations detected individually, and the detection rate of lesions in ¹⁸F-FDG PET/CT was higher than that of enhanced CT and MRI (P < 0.05).

Conclusion: The combination of MRI, enhanced CT and ¹⁸F-FDG PET/CT can accurately diagnose recurrence and metastasis of ovarian cancer after surgery, detect recurrent metastatic lesions as early as possible, and improve patients' prognosis.

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联合磁共振成像、增强 CT 和 18F-FDG PET/CT 在诊断卵巢癌术后复发和转移中的价值。

目的本文旨在探讨MRI、增强CT和18F-FDG PET/CT联合应用在卵巢癌术后复发和转移诊断中的价值：方法：选取95例卵巢癌患者作为研究对象，所有患者均接受了手术治疗，术后随访时均进行了MRI、增强CT和18F-FDG PET/CT检查，并将第二次手术后的病理结果作为诊断 "金标准"。比较三种检查方法单独或联合诊断卵巢癌术后复发和转移的诊断价值（敏感性、特异性、准确性、阴性预测值和阳性预测值），以病灶为研究单位计算检出率，从而比较三种方法在卵巢癌术后复发转移病灶诊断中的疗效：联合组对卵巢癌术后复发和转移的敏感性、特异性、准确性、阳性预测值和阴性预测值均高于MRI和增强CT，联合组的特异性、准确性和阳性预测值均高于18F-FDG PET/CT组，18F-FDG PET/CT组的特异性、准确性和阳性预测值均高于增强CT组（均P 18F-FDG PET/CT的特异性、准确性和阳性预测值均高于增强CT和MRI（P 结论：MRI、增强CT和联合组对卵巢癌术后复发和转移的敏感性、特异性、准确性、阳性预测值和阴性预测值均高于MRI和增强CT：MRI、增强CT和18F-FDG PET/CT联合应用可准确诊断卵巢癌术后复发和转移，尽早发现复发转移病灶，改善患者预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical & Translational Oncology 医学-肿瘤学

CiteScore

6.20

自引率

2.90%

发文量

240

审稿时长

1 months

期刊介绍： Clinical and Translational Oncology is an international journal devoted to fostering interaction between experimental and clinical oncology. It covers all aspects of research on cancer, from the more basic discoveries dealing with both cell and molecular biology of tumour cells, to the most advanced clinical assays of conventional and new drugs. In addition, the journal has a strong commitment to facilitating the transfer of knowledge from the basic laboratory to the clinical practice, with the publication of educational series devoted to closing the gap between molecular and clinical oncologists. Molecular biology of tumours, identification of new targets for cancer therapy, and new technologies for research and treatment of cancer are the major themes covered by the educational series. Full research articles on a broad spectrum of subjects, including the molecular and cellular bases of disease, aetiology, pathophysiology, pathology, epidemiology, clinical features, and the diagnosis, prognosis and treatment of cancer, will be considered for publication.