Gut Microbiota Modulation by Selenium and Zinc Enrichment Postbiotic on Dysbiosis Associated with Hypertension.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-01-01 DOI:10.2174/0115701611290537240509061549

Laura-Dorina Dinu, Florentina Gatea, Florentina Matei, Cristian Banciu, Emanuel Vamanu

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Abstract

Background: Targeting gut dysbiosis to treat chronic diseases or to alleviate the symptoms is a new direction for medical adjuvant therapies. Recently, postbiotics have received considerable attention as they are non-viable probiotic preparations that confer various health benefits to the host without the safety problems associated with using live microbial cells.

Objective: The aim of the study is to obtain selenium (Se) and zinc (Zn) enriched Saccharomyces boulardii postbiotic biomass and to analyze its modulation effect because these minerals play an important role in reducing gut dysbiosis linked to cardiovascular (CV) diseases.

Method: The effect of the S. boulardii and Se/Zn enriched yeast postbiotics on CV microbial fingerprint was studied in vitro using the gastrointestinal system (GIS 1) and analyzed by microbiological, chemical, and qPCR methods.

Result: There was a 2.2 log CFU/mL increase in the total bacterial load after SeZn postbiotic treatment and in the qPCR counts of Firmicutes phyla for both treatments. Beneficial taxa, Bifidobacterium spp. and Lactobacillus spp., as well as Bacteroidesspp. were up to 1.5 log higher after mineral- enriched postbiotic application, while the acetic acid level increased.

Conclusion: These preliminary studies highlight the therapeutic potential of using Se/Zn enriched yeast postbiotics as adjuvants for clinical treatments of CV diseases.

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硒和锌富集后益生菌对与高血压有关的菌群失调的肠道微生物群调节作用

背景：针对肠道菌群失调治疗慢性疾病或缓解症状是医学辅助疗法的一个新方向。最近，后益生菌受到了广泛关注，因为它们是不可存活的益生菌制剂，能为宿主带来各种健康益处，而不会出现与使用活微生物细胞相关的安全问题：本研究旨在获得富含硒（Se）和锌（Zn）的布拉氏酵母菌后益生菌生物质，并分析其调节作用，因为这些矿物质在减少与心血管疾病相关的肠道菌群失调方面发挥着重要作用：方法：利用胃肠系统（GIS 1）体外研究布拉氏酵母菌和富含硒/锌的酵母后生物质对心血管微生物指纹的影响，并通过微生物学、化学和qPCR方法进行分析：结果：SeZn 后益生菌处理后，总细菌量增加了 2.2 log CFU/mL，两种处理的固有菌门的 qPCR 计数也增加了 2.2 log CFU/mL。有益类群、双歧杆菌属和乳酸杆菌属以及乳酸杆菌属在使用富含矿物质的益生元后最多可增加 1.5 个对数值，而醋酸水平则有所增加：这些初步研究强调了使用富含硒/锌的酵母后生物质作为临床治疗冠心病的辅助剂的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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