Deciphering the Epigenetic Symphony of Cancer: Insights and Epigenetic Therapies Implications.

IF 2.7 4区医学 Q3 ONCOLOGY Technology in Cancer Research & Treatment Pub Date : 2024-01-01 DOI:10.1177/15330338241250317

Fatima Akram, Rida Tanveer, Sahar Andleeb, Fatima Iftikhar Shah, Tayyab Ahmad, Somia Shehzadi, Abdul Majeed Akhtar, Ghania Syed

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Abstract

Epigenetic machinery is a cornerstone in normal cell development, orchestrating tissue-specific gene expression in mammalian cells. Aberrations in this intricate landscape drive substantial changes in gene function, emerging as a linchpin in cancer etiology and progression. While cancer was conventionally perceived as solely a genetic disorder, its contemporary definition encompasses genetic alterations intertwined with disruptive epigenetic abnormalities. This review explores the profound impact of DNA methylation, histone modifications, and noncoding RNAs on fundamental cellular processes. When these pivotal epigenetic mechanisms undergo disruption, they intricately guide the acquisition of the 6 hallmark characteristics of cancer within seemingly normal cells. Leveraging the latest advancements in decoding these epigenetic intricacies holds immense promise, heralding a new era in developing targeted and more efficacious treatment modalities against cancers driven by aberrant epigenetic modifications.

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解密癌症的表观遗传交响乐：洞察力和表观遗传疗法的意义。

表观遗传机制是正常细胞发育的基石，它协调着哺乳动物细胞中组织特异性基因的表达。这一错综复杂的机制出现异常，会导致基因功能发生重大变化，成为癌症病因和进展的关键因素。尽管癌症在传统上被认为仅仅是一种遗传性疾病，但其现代定义却包含了与破坏性表观遗传异常交织在一起的遗传改变。本综述探讨了 DNA 甲基化、组蛋白修饰和非编码 RNA 对基本细胞过程的深远影响。当这些关键的表观遗传学机制受到破坏时，它们就会错综复杂地引导看似正常的细胞获得癌症的 6 个标志性特征。利用解码这些错综复杂的表观遗传学的最新进展前景广阔，预示着针对由异常表观遗传修饰驱动的癌症开发更有效的靶向治疗模式的新时代即将到来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Technology in Cancer Research & Treatment 医学-肿瘤学

CiteScore

4.40

自引率

0.00%

发文量

202

审稿时长

2 months

期刊介绍： Technology in Cancer Research & Treatment (TCRT) is a JCR-ranked, broad-spectrum, open access, peer-reviewed publication whose aim is to provide researchers and clinicians with a platform to share and discuss developments in the prevention, diagnosis, treatment, and monitoring of cancer.