Unravelling the complexity of the mitochondrial Ca2+ uniporter: regulation, tissue specificity, and physiological implications

IF 4.3 2区 生物学 Q2 CELL BIOLOGY Cell calcium Pub Date : 2024-05-23 DOI:10.1016/j.ceca.2024.102907
Denis Vecellio Reane , Julian D.C. Serna , Anna Raffaello
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Abstract

Calcium (Ca2+) signalling acts a pleiotropic message within the cell that is decoded by the mitochondria through a sophisticated ion channel known as the Mitochondrial Ca2+ Uniporter (MCU) complex. Under physiological conditions, mitochondrial Ca2+ signalling is crucial for coordinating cell activation with energy production. Conversely, in pathological scenarios, it can determine the fine balance between cell survival and death. Over the last decade, significant progress has been made in understanding the molecular bases of mitochondrial Ca2+ signalling. This began with the elucidation of the MCU channel components and extended to the elucidation of the mechanisms that regulate its activity. Additionally, increasing evidence suggests molecular mechanisms allowing tissue-specific modulation of the MCU complex, tailoring channel activity to the specific needs of different tissues or cell types. This review aims to explore the latest evidence elucidating the regulation of the MCU complex, the molecular factors controlling the tissue-specific properties of the channel, and the physiological and pathological implications of mitochondrial Ca2+ signalling in different tissues.

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揭示线粒体 Ca2+ 单向传输器的复杂性:调节、组织特异性和生理意义
钙(Ca2+)信号是细胞内的一种多向信息,由线粒体通过称为线粒体 Ca2+ 单通道(MCU)复合体的复杂离子通道进行解码。在生理条件下,线粒体 Ca2+ 信号对于协调细胞活化和能量生产至关重要。相反,在病理情况下,它可以决定细胞存活与死亡之间的微妙平衡。过去十年来,在了解线粒体 Ca2+ 信号的分子基础方面取得了重大进展。这始于对 MCU 通道成分的阐明,并延伸到对其活性调节机制的阐明。此外,越来越多的证据表明,分子机制允许对 MCU 复合物进行组织特异性调节,使通道活性适应不同组织或细胞类型的特定需要。本综述旨在探讨阐明 MCU 复合物调控的最新证据、控制通道组织特异性的分子因素以及线粒体 Ca2+ 信号在不同组织中的生理和病理影响。
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来源期刊
Cell calcium
Cell calcium 生物-细胞生物学
CiteScore
8.70
自引率
5.00%
发文量
115
审稿时长
35 days
期刊介绍: Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes
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