Relationship between Femoral Proximal Bone Quality Assessment by MRI IDEAL-IQ Sequence and Body Mass Index in Elderly Men.

IF 2.2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Tomography Pub Date : 2024-05-20 DOI:10.3390/tomography10050062

Kashia Goto, Daisuke Watanabe, Norikazu Kawae, Takahiro Nakamura, Kazuki Yanagida, Takahiro Yoshida, Hajime Kajihara, Akio Mizushima

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Abstract

Background: Bone assessment using the MRI DEAL-IQ sequence may have the potential to serve as a substitute for evaluating bone strength by quantifying the bone marrow hematopoietic region (R2*) and marrow adiposity (proton density fat fraction: PDFF). Higher body mass index (BMI) is associated with increased bone mineral density (BMD) in the proximal femur; however, the relationship between BMI and R2* or PDFF remains unclear. Herein, we investigated the correlation between BMI and MRI IDEAL-IQ based R2* or PDFF of the proximal femur.

Methods: A retrospective single-cohort study was conducted on 217 patients diagnosed with non-metastatic prostate cancer between September 2019 and December 2022 who underwent MRI. The correlation between BMI and R2* or PDFF of the proximal femur was analyzed using Spearman's rank correlation test.

Results: Among 217 patients (median age, 74 years; median BMI, 23.8 kg/m²), there was a significant positive correlation between BMI and R2* at the right and left proximal femur (r = 0.2686, p < 0.0001; r = 0.2755, p < 0.0001, respectively). Furthermore, BMI and PDFF showed a significant negative correlation (r = -0.239, p = 0.0004; r = -0.2212, p = 0.001, respectively).

Conclusion: In elderly men, the increased loading on the proximal femur due to elevated BMI was observed to promote a decrease in bone marrow adiposity in the proximal femur, causing a tendency for a transition from fatty marrow to red marrow with hematopoietic activity. These results indicate that the MRI IDEAL-IQ sequence may be valuable for assessing bone quality deterioration in the proximal femur.

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核磁共振成像 IDEAL-IQ 序列的股骨近端骨质评估与老年男性体重指数之间的关系

背景：使用核磁共振 DEAL-IQ 序列进行骨质评估，通过量化骨髓造血区域（R2*）和骨髓脂肪含量（质子密度脂肪分数：PDFF），有可能替代骨强度评估。较高的体重指数（BMI）与股骨近端骨矿物质密度（BMD）的增加有关；然而，BMI 与 R2* 或 PDFF 之间的关系仍不清楚。在此，我们研究了 BMI 与基于 MRI IDEAL-IQ 的股骨近端 R2* 或 PDFF 之间的相关性：我们对 2019 年 9 月至 2022 年 12 月期间诊断为非转移性前列腺癌并接受 MRI 检查的 217 名患者进行了回顾性单队列研究。采用斯皮尔曼秩相关检验分析了BMI与股骨近端R2*或PDFF之间的相关性：在 217 名患者（中位年龄 74 岁；中位体重指数 23.8 kg/m2）中，体重指数与左右股骨近端 R2* 呈显著正相关（分别为 r = 0.2686，p < 0.0001；r = 0.2755，p < 0.0001）。此外，BMI 和 PDFF 呈显著负相关（分别为 r = -0.239，p = 0.0004；r = -0.2212，p = 0.001）：结论：在老年男性中，观察到由于体重指数升高导致股骨近端负荷增加，从而促进了股骨近端骨髓脂肪含量的降低，造成了从脂肪骨髓向具有造血活性的红骨髓过渡的趋势。这些结果表明，核磁共振成像 IDEAL-IQ 序列可能对评估股骨近端骨质退化很有价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tomography Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

2.70

自引率

10.50%

发文量

222

期刊介绍： TomographyTM publishes basic (technical and pre-clinical) and clinical scientific articles which involve the advancement of imaging technologies. Tomography encompasses studies that use single or multiple imaging modalities including for example CT, US, PET, SPECT, MR and hyperpolarization technologies, as well as optical modalities (i.e. bioluminescence, photoacoustic, endomicroscopy, fiber optic imaging and optical computed tomography) in basic sciences, engineering, preclinical and clinical medicine. Tomography also welcomes studies involving exploration and refinement of contrast mechanisms and image-derived metrics within and across modalities toward the development of novel imaging probes for image-based feedback and intervention. The use of imaging in biology and medicine provides unparalleled opportunities to noninvasively interrogate tissues to obtain real-time dynamic and quantitative information required for diagnosis and response to interventions and to follow evolving pathological conditions. As multi-modal studies and the complexities of imaging technologies themselves are ever increasing to provide advanced information to scientists and clinicians. Tomography provides a unique publication venue allowing investigators the opportunity to more precisely communicate integrated findings related to the diverse and heterogeneous features associated with underlying anatomical, physiological, functional, metabolic and molecular genetic activities of normal and diseased tissue. Thus Tomography publishes peer-reviewed articles which involve the broad use of imaging of any tissue and disease type including both preclinical and clinical investigations. In addition, hardware/software along with chemical and molecular probe advances are welcome as they are deemed to significantly contribute towards the long-term goal of improving the overall impact of imaging on scientific and clinical discovery.