Beyond Immune Checkpoint Inhibitors: Emerging Targets in Melanoma Therapy.

IF 4.7 2区 医学 Q1 ONCOLOGY Current Oncology Reports Pub Date : 2024-07-01 Epub Date: 2024-05-25 DOI:10.1007/s11912-024-01551-4
Andrew D Knight, Jason J Luke
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Abstract

Purpose of review: This review provides a comprehensive update on recent advancements in melanoma treatment by highlighting promising therapeutics with an aim to increase awareness of novel interventions currently in development.

Recent findings: Over the last decade there has been considerable expansion of the previously available treatment options for patients with melanoma. In particular, novel immunotherapeutics have been developed to expand on the clinical advancements brought by BRAF targeting and immune checkpoint inhibitors. Despite the success of checkpoint inhibitors there remains an unmet need for patients that do not respond to treatment. This review delves into the latest advancements in novel checkpoint inhibitors, cytokines, oncolytic viruses, vaccines, bispecific antibodies, and adoptive cell therapy. Preclinical experiments and early-stage clinical trials studies have demonstrated promising results for these therapies, many of which have moved into pivotal, phase 3 studies.

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超越免疫检查点抑制剂:黑色素瘤治疗中的新靶点。
综述的目的:本综述全面介绍了黑色素瘤治疗的最新进展,重点介绍了前景看好的治疗方法,旨在提高人们对目前正在开发的新型干预措施的认识:在过去十年中,黑色素瘤患者的现有治疗方案有了很大的扩展。特别是,新型免疫疗法的开发扩大了BRAF靶向药物和免疫检查点抑制剂带来的临床进展。尽管检查点抑制剂取得了成功,但对治疗无反应的患者的需求仍未得到满足。本综述将深入探讨新型检查点抑制剂、细胞因子、溶瘤病毒、疫苗、双特异性抗体和收养细胞疗法的最新进展。这些疗法的临床前实验和早期临床试验研究已取得了令人鼓舞的成果,其中许多疗法已进入关键的第三阶段研究。
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来源期刊
CiteScore
8.50
自引率
0.00%
发文量
187
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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