Salivary cortisol levels in patients with potentially malignant oral disorders and oral mucosal cancer: a case-control study.

IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Medicina Oral Patologia Oral Y Cirugia Bucal Pub Date : 2024-09-01 DOI:10.4317/medoral.26606
E López-D'alessandro, J Palomino, L Escovich
{"title":"Salivary cortisol levels in patients with potentially malignant oral disorders and oral mucosal cancer: a case-control study.","authors":"E López-D'alessandro, J Palomino, L Escovich","doi":"10.4317/medoral.26606","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The relationship between salivary cortisol secretion and the presence of cancer in the oral cavity has not been completely clarified. Due to this, we proposed carrying out a study to determine salivary cortisol levels in patients with potentially malignant disorders (PMD), oral squamous cell carcinoma (OSCC) and healthy individuals.</p><p><strong>Material and methods: </strong>Cross-sectional case-control study, among 80 patients seen at the Faculty of Dentistry of the National University of Rosario, Argentina, between January 2018 and April 2020. 40 cases represented by Leukoplakia, Lichen, Erythroplakia and SCC and 40 controls were included. Smoking habit and alcohol consumption were included. The presence of stress was determined. Morning salivary cortisol levels were measured with the Roche electrochemiluminescence method (Traceability: St by ID-MS).</p><p><strong>Results: </strong>Patients with SCC presented elevated salivary cortisol values. Individuals with stage III tumors showed levels higher than 8.74 ng/ml in all cases. A significant association between cortisol levels and stress was detected in patients in the control group (p<0.005) and in individuals with PMD (p=0.009). This association was not significant in patients with SCC (p=0.999). After applying the logistic regression method, when adjusting odds ratios according to tobacco and alcohol consumption and the presence of stress, the association between cortisol levels and presence of stress was highly significant (p<0.001). The possibility of presenting undetectable cortisol results was 94% lower in patients with stress.</p><p><strong>Conclusions: </strong>The increase in salivary cortisol levels in patients with PMD and SCC, is related to stress conditions, being able to generate alterations tending to immunosuppression of the cellular microenvironment.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e644-e649"},"PeriodicalIF":1.8000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365055/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina Oral Patologia Oral Y Cirugia Bucal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4317/medoral.26606","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0

Abstract

Background: The relationship between salivary cortisol secretion and the presence of cancer in the oral cavity has not been completely clarified. Due to this, we proposed carrying out a study to determine salivary cortisol levels in patients with potentially malignant disorders (PMD), oral squamous cell carcinoma (OSCC) and healthy individuals.

Material and methods: Cross-sectional case-control study, among 80 patients seen at the Faculty of Dentistry of the National University of Rosario, Argentina, between January 2018 and April 2020. 40 cases represented by Leukoplakia, Lichen, Erythroplakia and SCC and 40 controls were included. Smoking habit and alcohol consumption were included. The presence of stress was determined. Morning salivary cortisol levels were measured with the Roche electrochemiluminescence method (Traceability: St by ID-MS).

Results: Patients with SCC presented elevated salivary cortisol values. Individuals with stage III tumors showed levels higher than 8.74 ng/ml in all cases. A significant association between cortisol levels and stress was detected in patients in the control group (p<0.005) and in individuals with PMD (p=0.009). This association was not significant in patients with SCC (p=0.999). After applying the logistic regression method, when adjusting odds ratios according to tobacco and alcohol consumption and the presence of stress, the association between cortisol levels and presence of stress was highly significant (p<0.001). The possibility of presenting undetectable cortisol results was 94% lower in patients with stress.

Conclusions: The increase in salivary cortisol levels in patients with PMD and SCC, is related to stress conditions, being able to generate alterations tending to immunosuppression of the cellular microenvironment.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
潜在恶性口腔疾病和口腔黏膜癌患者的唾液皮质醇水平:一项病例对照研究。
背景:唾液皮质醇分泌与口腔癌之间的关系尚未完全明确。因此,我们建议开展一项研究,以确定潜在恶性疾病(PMD)、口腔鳞状细胞癌(OSCC)患者和健康人的唾液皮质醇水平:横断面病例对照研究,对象为2018年1月至2020年4月期间在阿根廷罗萨里奥国立大学牙科学院就诊的80名患者。其中包括 40 例白斑病、苔癣、红斑和 SCC 病例,以及 40 例对照病例。研究还包括吸烟和饮酒习惯。确定是否存在压力。采用罗氏电化学发光法(可追溯性:St by ID-MS)测量早晨唾液皮质醇水平:结果:SCC 患者的唾液皮质醇值升高。所有 III 期肿瘤患者的皮质醇水平均高于 8.74 纳克/毫升。在对照组患者中,皮质醇水平与压力之间存在明显联系(p结论:唾液皮质醇的升高与压力有关:PMD 和 SCC 患者唾液中皮质醇水平的升高与压力条件有关,可导致细胞微环境免疫抑制的改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Medicina Oral Patologia Oral Y Cirugia Bucal
Medicina Oral Patologia Oral Y Cirugia Bucal DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
4.60
自引率
0.00%
发文量
52
审稿时长
3-8 weeks
期刊介绍: 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology
期刊最新文献
Novel topical dressing for dry socket and comparison of its efficacy with that of Alvogyl®: A randomized controlled clinical trial. Oral pathology in a population observed within an oral cancer screening developed in Portugal. Relationship between periodontitis and chronic obstructive pulmonary disease: a bibliometric analysis from 1945 to 2023. Telediagnosis performance of specialists in oral medicine and general dental practitioner using images of oral mucosa lesions in Chile. The 100 most influential articles in mouth breathing. A bibliometric and altmetric analysis: 2002-2021.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1