Survival analysis of the surgical treatment of hepatocellular carcinoma at a tertiary care center

{"title":"Survival analysis of the surgical treatment of hepatocellular carcinoma at a tertiary care center","authors":"","doi":"10.1016/j.rgmxen.2022.12.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction and aims</h3><p>Hepatocellular carcinoma (HCC) is a primary malignant tumor of liver epithelial cells and is the most frequent primary liver cancer. The broadening of transplantation and resectability criteria has made therapeutic decisions more complex. Our aim was to describe the clinical and survival characteristics of patients with HCC treated through resection or liver transplantation at our hospital and identify the presence of factors that enable outcome prediction and facilitate therapeutic decision-making.</p></div><div><h3>Materials and methods</h3><p>Patients with HCC that underwent surgery with curative intent at the <em>Hospital Universitario Marqués de Valdecilla</em>, within the time frame of 2007 and 2017, were retrospectively identified. Survival, mortality, disease-free interval, and different outcome-related variables were analyzed.</p></div><div><h3>Results</h3><p>Ninety-six patients with a mean follow-up after surgery of 44 months were included. Overall mortality and recurrence were higher in the resection group. Mean survival was 51.4 months in the liver transplantation group and 37.5 months in the resection group, and the disease-free interval was 49.4 ± 37.2 and 27.4 ± 28.7 months, respectively (p = 0.002). The tumor burden score was statistically significant regarding risk for recurrence and specific mortality.</p></div><div><h3>Conclusions</h3><p>There appears to be no patient subgroup in whom the results of surgical resection were superior or comparable to those of transplantation. Tumor burden determination could be a useful tool for patient subclassification and help guide therapeutic decision-making.</p></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 3","pages":"Pages 323-331"},"PeriodicalIF":0.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X24000392/pdfft?md5=ccfbfbb8ad720031933157b65cff1b4c&pid=1-s2.0-S2255534X24000392-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista de gastroenterologia de Mexico (English)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2255534X24000392","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction and aims

Hepatocellular carcinoma (HCC) is a primary malignant tumor of liver epithelial cells and is the most frequent primary liver cancer. The broadening of transplantation and resectability criteria has made therapeutic decisions more complex. Our aim was to describe the clinical and survival characteristics of patients with HCC treated through resection or liver transplantation at our hospital and identify the presence of factors that enable outcome prediction and facilitate therapeutic decision-making.

Materials and methods

Patients with HCC that underwent surgery with curative intent at the Hospital Universitario Marqués de Valdecilla, within the time frame of 2007 and 2017, were retrospectively identified. Survival, mortality, disease-free interval, and different outcome-related variables were analyzed.

Results

Ninety-six patients with a mean follow-up after surgery of 44 months were included. Overall mortality and recurrence were higher in the resection group. Mean survival was 51.4 months in the liver transplantation group and 37.5 months in the resection group, and the disease-free interval was 49.4 ± 37.2 and 27.4 ± 28.7 months, respectively (p = 0.002). The tumor burden score was statistically significant regarding risk for recurrence and specific mortality.

Conclusions

There appears to be no patient subgroup in whom the results of surgical resection were superior or comparable to those of transplantation. Tumor burden determination could be a useful tool for patient subclassification and help guide therapeutic decision-making.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
一家三级医疗中心肝细胞癌手术治疗的存活率分析。
导言和目的:肝细胞癌(HCC)是肝上皮细胞的原发性恶性肿瘤,也是最常见的原发性肝癌。移植和可切除标准的扩大使治疗决策变得更加复杂。我们的目的是描述本院通过切除术或肝移植治疗的 HCC 患者的临床和生存特征,并确定是否存在可预测结果和促进治疗决策的因素:对2007年至2017年期间在巴尔德西亚侯爵大学医院(Hospital Universitario Marqués de Valdecilla)接受治愈性手术的HCC患者进行了回顾性鉴定。分析了患者的生存率、死亡率、无病间隔期以及不同的结果相关变量:共纳入96名患者,术后平均随访44个月。切除组的总死亡率和复发率较高。肝移植组的平均生存期为 51.4 个月,切除组为 37.5 个月,无病间隔时间分别为 49.4 ± 37.2 个月和 27.4 ± 28.7 个月(P = 0.002)。肿瘤负荷评分对复发风险和特定死亡率有统计学意义:结论:似乎没有哪个亚组患者的手术切除效果优于或类似于移植手术。肿瘤负荷测定可作为患者亚分类的有用工具,并有助于指导治疗决策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
审稿时长
12 weeks
期刊最新文献
Clinical utility of the solid meal test during high-resolution esophageal manometry. A study in a Latin American population. Rice and esophageal motility. Weight change and lifestyle modifications implemented during the COVID-19 pandemic lockdown are associated with the development of gastrointestinal symptoms. Colorectal adenocarcinoma in children and adolescents. Comparative evaluation of APRI, FIB-4, HFS, and NFS: Scoring tools for liver fibrosis in a Mexican population with MASLD.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1