The alarming link between neonicotinoid insecticides and kidney injury

IF 5.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Emerging Contaminants Pub Date : 2024-05-22 DOI:10.1016/j.emcon.2024.100376

Zhanpeng Zhang , Longbin Shen , Mei Chen , Biao Huang , Zhuoqi Wei , Weiguo Xu , Hua Zhang

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Abstract

Neonicotinoid insecticides (NEOs) have been extensively approved for application in agricultural production both in China and globally. Previous studies indicated that human exposure to NEOs would have adverse health effects. However, studies on occurrences of NEOs in kidney injury patients and their association with nephrotoxicity are limited. This study investigates the potential correlation between exposure to NEOs and kidney injury within a subset (n = 224) of the population residing in South China. Levels of 8 NEOs and 5 metabolites were quantified in blood samples obtained from both the 110 healthy and 114 kidney injury cohorts in South China. We found that target analytes were frequently detected in samples from the healthy and kidney injury cohorts (61%–100 %). Dinotefuran is the predominant NEO in the healthy (42.3 %) and kidney injury cohort (49.6 %). Significantly positive (p < 0.05) associations between blood NEO concentrations and kidney injury were found, indicating that these pollutants may increase the odds of human kidney injury prevalence. Through multilinear regression analysis, it was observed that the concentrations of various NEOs exhibited a significant association (p < 0.05) with hematological parameters linked to nephrotoxicity. Our study represents the pioneering investigation examining the relationships between NEOs and kidney injury, thereby offering novel insights into the nephrotoxicity associated with these pollutants. This discovery carries significant implications for public health policies and environmental conservation practices.

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新烟碱类杀虫剂与肾损伤之间令人震惊的联系

新烟碱类杀虫剂（NEOs）已被广泛批准用于中国和全球的农业生产。以往的研究表明，人类接触 NEOs 会对健康产生不良影响。然而，有关肾损伤患者体内 NEOs 的发生率及其与肾毒性之间关系的研究十分有限。本研究调查了居住在华南地区的部分人群（n = 224）暴露于近地物体与肾损伤之间的潜在相关性。我们对华南地区 110 名健康人群和 114 名肾损伤人群的血液样本中 8 种近地天体和 5 种代谢物的水平进行了量化。我们发现，在健康人群和肾损伤人群的样本中都能频繁检测到目标分析物（61%-100%）。在健康人群（42.3%）和肾损伤人群（49.6%）中，主要的近地天敌是呋喃丹。研究发现，血液中的 NEO 浓度与肾损伤之间存在显著的正相关关系（p < 0.05），这表明这些污染物可能会增加人体肾损伤患病率。通过多线性回归分析发现，各种近地天体的浓度与与肾毒性相关的血液学参数有显著关联（p < 0.05）。我们的研究开创性地探讨了近地物体与肾损伤之间的关系，从而为了解与这些污染物相关的肾毒性提供了新的视角。这一发现对公共卫生政策和环境保护实践具有重要意义。

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来源期刊

Emerging Contaminants Medicine-Public Health, Environmental and Occupational Health

CiteScore

10.00

自引率

6.70%

发文量

审稿时长

44 days

期刊介绍： Emerging Contaminants is an outlet for world-leading research addressing problems associated with environmental contamination caused by emerging contaminants and their solutions. Emerging contaminants are defined as chemicals that are not currently (or have been only recently) regulated and about which there exist concerns regarding their impact on human or ecological health. Examples of emerging contaminants include disinfection by-products, pharmaceutical and personal care products, persistent organic chemicals, and mercury etc. as well as their degradation products. We encourage papers addressing science that facilitates greater understanding of the nature, extent, and impacts of the presence of emerging contaminants in the environment; technology that exploits original principles to reduce and control their environmental presence; as well as the development, implementation and efficacy of national and international policies to protect human health and the environment from emerging contaminants.