Dried fruit intake can lower the risk of ulcerative colitis: evidence from a Mendelian randomization study.

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS Asia Pacific journal of clinical nutrition Pub Date : 2024-06-01 DOI:10.6133/apjcn.202406_33(2).0010
Zhijun Bu, Xuehui Wang, Xuefeng Wang, Zhirui Huang, Zhaoxia Feng, Xueping Huang, Pengyu Wang, Nan Jiang, Feng Xu, Jianping Liu, Zhaolan Liu
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Abstract

Background and objectives: This study aims to examine the causal relationship between dietary factors and ulcerative colitis (UC).

Methods and study design: The analysis utilized data from genome-wide association studies (GWAS). Dried fruit, vegetables, processed meat, fresh fruit, and cereal intake were examined as exposure factors. UC was considered the outcome. Two-sample Mendelian randomization (TSMR) analysis was performed using methods. Heterogeneity and horizontal pleiotropy assessments were conducted to ensure the robustness of our findings. Additionally, we applied False Discovery Rate (FDR) corrections for multiple tests.

Results: The analysis revealed a significant inverse causal relationship between dried fruit intake and UC risk (odds ratio [OR]: 0.488, 95% confidence interval [CI]: 0.261 to 0.915, p = 0.025). No significant association was observed between vegetable intake (OR: 1.742, 95% CI: 0.561 to 5.415, p = 0.337), processed meat intake (OR: 1.136, 95% CI: 0.552 to 2.339, p = 0.729), fresh fruit intake (OR: 0.977, 95% CI: 0.465 to 2.054, p = 0.952), cereal intake (OR: 1.195, 95% CI: 0.669 to 2.134, p = 0.547). The low heterogeneity observed across analyses and the confirmation of stability through leave-one-out analysis reinforce the reliability of these results. Moreover, after adjusting for multiple tests, none of the dietary factors reached a p-value below the conventional significance threshold of 0.05.

Conclusions: This study provides evidence of a potential association between dried fruit intake and a reduced risk of UC. Further MR studies incorporating larger GWAS datasets are needed to confirm these findings.

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干果摄入可降低溃疡性结肠炎的风险:孟德尔随机研究的证据。
背景和目的:本研究旨在探讨饮食因素与溃疡性结肠炎(UC)的因果关系:本研究旨在探讨饮食因素与溃疡性结肠炎(UC)之间的因果关系:分析利用了全基因组关联研究(GWAS)的数据。干果、蔬菜、加工肉类、新鲜水果和谷物摄入量作为暴露因素进行研究。UC 被认为是结果。采用双样本孟德尔随机化(TSMR)方法进行分析。为确保研究结果的稳健性,我们进行了异质性和水平多效性评估。此外,我们还对多重检验进行了错误发现率(FDR)校正:结果:分析表明,干果摄入量与 UC 风险之间存在明显的反向因果关系(几率比 [OR]:0.488,95% 置信区间 [CI]:0.261至0.915,P = 0.025)。在蔬菜摄入量(OR:1.742,95% CI:0.561 至 5.415,p = 0.337)、加工肉类摄入量(OR:1.136,95% CI:0.552 至 2.339,p = 0.729)、新鲜水果摄入量(OR:0.977,95% CI:0.465 至 2.054,p = 0.952)、谷物摄入量(OR:1.195,95% CI:0.669 至 2.134,p = 0.547)之间未观察到明显关联。不同分析之间的异质性较低,而且通过剔除分析确认了稳定性,这些都增强了研究结果的可靠性。此外,经过多重测试调整后,没有一个饮食因素的 p 值低于 0.05 的常规显著性阈值:本研究提供了干果摄入量与降低 UC 风险之间潜在联系的证据。要证实这些发现,还需要结合更大的全球基因组研究数据集开展进一步的磁共振研究。
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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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