Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles

IF 0.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Doklady Biochemistry and Biophysics Pub Date : 2024-05-25 DOI:10.1134/S1607672924700819

M. V. Filimonova, D. D. Kolmanovich, G. V. Tikhonowski, D. S. Petrunya, P. A. Kotelnikova, A. A. Shitova, O. V. Soldatova, A. S. Filimonov, V. A. Rybachuk, A. O. Kosachenko, K. A. Nikolaev, G. A. Demyashkin, A. A. Popov, M. S. Savinov, A. L. Popov, I. V. Zelepukin, A. A. Lipengolts, K. E. Shpakova, A. V. Kabashin, S. N. Koryakin, S. M. Deyev, I. N. Zavestovskaya

{"title":"Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles","authors":"M. V. Filimonova, D. D. Kolmanovich, G. V. Tikhonowski, D. S. Petrunya, P. A. Kotelnikova, A. A. Shitova, O. V. Soldatova, A. S. Filimonov, V. A. Rybachuk, A. O. Kosachenko, K. A. Nikolaev, G. A. Demyashkin, A. A. Popov, M. S. Savinov, A. L. Popov, I. V. Zelepukin, A. A. Lipengolts, K. E. Shpakova, A. V. Kabashin, S. N. Koryakin,  S. M. Deyev, I. N. Zavestovskaya","doi":"10.1134/S1607672924700819","DOIUrl":null,"url":null,"abstract":"<p>Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete death of EMT6/P cells in vitro. Binary proton therapy using targeted Au-PEG-FA nanoparticles caused an 80% tumor growth inhibition effect in vivo. The use of targeted gold nanoparticles is promising for enhancing the proton irradiation effect on tumor cells and requires further research to increase the therapeutic index of the approach.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"516 1","pages":"111 - 114"},"PeriodicalIF":0.8000,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Doklady Biochemistry and Biophysics","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1134/S1607672924700819","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete death of EMT6/P cells in vitro. Binary proton therapy using targeted Au-PEG-FA nanoparticles caused an 80% tumor growth inhibition effect in vivo. The use of targeted gold nanoparticles is promising for enhancing the proton irradiation effect on tumor cells and requires further research to increase the therapeutic index of the approach.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

利用靶向金纳米粒子对艾氏癌进行双质子治疗

质子疗法可以治疗位于辐射敏感组织中的肿瘤。本文展示了利用能选择性识别肿瘤细胞的靶向金纳米粒子增强质子疗法的可能性。浓度高于 25 mg/L 的 Au-PEG 纳米粒子和 4 Gy 质子剂量在体外可导致 EMT6/P 细胞完全死亡。使用靶向 Au-PEG-FA 纳米粒子的二元质子疗法在体内可抑制 80% 的肿瘤生长。靶向金纳米粒子的使用有望增强质子辐照对肿瘤细胞的作用，需要进一步研究以提高该方法的治疗指数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Doklady Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

1.60

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.