Oral tobacco-free nicotine products: Quality and safety during storage

IF 17.7 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-05-23 DOI:10.21603/2308-4057-2025-1-635
Nikita Pankov, Anastasia Lushnikova, Tatiyana Perezhogina, Evgeniya Gnuchikh, Vladimir Lobanov, Tamara Vanitskaya
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Abstract

Oral non-tobacco nicotine products have gained enormous popularity in recent years. The countries of the Eurasian Economic Union also produce and sell this type of innovative but poorly studied goods. As a result, the safety profile and quality of such products as nicotine poaches require urgent comprehensive research. This study featured the changes in quality of nicotine poaches during storage, i.e. nicotine content, water activity, and microbiological index. The research featured nicotine poaches of several popular brands. The authors used standard research methods; the experiments were performed in the laboratory for chemistry and quality control, Institute of Tobacco, Makhorka, and Tobacco Products, Krasnodar, and at the Department of Bioorganic Chemistry and Technical Microbiology, Kuban State Technological University, Krasnodar. The water activity was 0.8911–0.9502 Aw at the initial stage and remained stable in most samples even after six months of storage. Velo Freeze was the only brand to show significant variations in water activity. The nicotine content was 10.115–12.950 mg/g at the initial stage. Only four samples maintained the initial values after six months of storage. The fluctuations of nicotine content were also mentioned by the manufacturer. The microbiological profile remained stable during the six months of storage and met the requirements for similar products, i.e., chewing gum and unglazed caramel. The project needs further research because the qualitative characteristics of nicotine poaches provided rather unambiguous results. Our study will help develop state standards for oral nicotine products. The results obtained will be used to formulate proposals to the organizations responsible for the future Technical Regulations of the Eurasian Economic Union for nicotine products.
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口服无烟尼古丁产品:储存期间的质量和安全
近年来,口服非烟草尼古丁产品大受欢迎。欧亚经济联盟国家也生产和销售此类创新但研究不足的产品。因此,亟需对尼古丁口服液等产品的安全性能和质量进行全面研究。本研究的重点是尼古丁水煮鱼在储存过程中的质量变化,即尼古丁含量、水分活性和微生物指数。研究对象是几种流行品牌的尼古丁水煮鱼。作者采用了标准的研究方法;实验在克拉斯诺达尔市烟草、Makhorka 和烟草制品研究所化学和质量控制实验室以及克拉斯诺达尔市库班国立技术大学生物有机化学和技术微生物学系进行。初始阶段的水活性为 0.8911-0.9502 Aw,大多数样品在储存 6 个月后仍保持稳定。Velo Freeze 是唯一一个水活性出现明显变化的品牌。初始阶段的尼古丁含量为 10.115-12.950 毫克/克。只有 4 个样品在存放 6 个月后仍保持初始值。生产商也提到了尼古丁含量的波动。在六个月的储存过程中,微生物含量保持稳定,符合类似产品(即口香糖和无釉焦糖)的要求。该项目需要进一步研究,因为尼古丁水煮糖的质量特性提供了相当明确的结果。我们的研究将有助于制定口服尼古丁产品的国家标准。获得的结果将用于向负责未来《欧亚经济联盟尼古丁产品技术条例》的组织提出建议。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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