Smart Polymer Systems: A Futuristic Approach to Enhance Therapeutic Efficacy

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-05-20 DOI:10.2174/0113852728305580240429100851

A. K. Seth, Ghanshyam Parmar, C. Aundhia, Nirmal Shah, D. Gohil

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Abstract

Recently, pharmaceutical industries have placed considerable emphasis on formulating drug delivery systems that precisely target specific sites, optimize drug utilization, minimize excipient usage, and mitigate side effects. Smart polymers hold tremendous promise in the design of innovative formulations tailored to deliver drugs with enhanced precision, efficacy, and therapeutic benefits while minimizing adverse effects. Within drug delivery, smart polymers demonstrate exceptional potential in achieving controlled and targeted release profiles, ensuring drug delivery to specific receptors, and minimizing off-target effects. This comprehensive review article focuses on the latest developments in smart polymers, primarily in the domains of drug delivery. By intelligently responding to external stimuli, smart polymer-based materials offer various applications, making them pivotal in modern pharmaceutical research. By utilizing the remarkable attributes of smart polymers, researchers and industry stakeholders can forge a path toward personalized, efficient, and patient-centric therapies with reduced side effects, propelling the pharmaceutical field into an era of unprecedented advancements.

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智能聚合物系统：增强疗效的未来方法

近来，制药业十分重视配制精确靶向特定部位、优化药物利用率、最大限度减少辅料用量和减轻副作用的给药系统。智能聚合物在设计创新制剂方面大有可为，这些制剂可提高给药的精确性、有效性和治疗效果，同时将不良反应降至最低。在给药方面，智能聚合物在实现可控和靶向释放、确保向特定受体给药以及最大限度地减少脱靶效应方面表现出非凡的潜力。这篇综述文章重点介绍了智能聚合物的最新发展，主要是在给药领域。通过对外界刺激做出智能响应，智能聚合物材料可提供多种应用，在现代药物研究中具有举足轻重的地位。通过利用智能聚合物的卓越特性，研究人员和行业利益相关者可以开辟一条通往个性化、高效、以患者为中心且副作用更小的疗法的道路，推动制药领域进入一个前所未有的进步时代。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.