Application of Nanotechnology as a Novel Approach to the Treatment of Skin Cancer

Q2 Pharmacology, Toxicology and Pharmaceutics Current Bioactive Compounds Pub Date : 2024-05-20 DOI:10.2174/0115734072320056240513054917

Sonia Singh, Aman Gupta, Mahima Varshney

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Abstract

Skin cancer has become the fifth most frequently reported form of cancer worldwide, imposing significant economic and public health challenges. Over the course of the last ten years, there has been a significant increase in the application of Nanoparticles (NPs) as a method of therapeutic administration to target skin cancer. The information has been gathered from many online databases, such as Scopus, Pubmed, Science Direct, and Web of Science, among others. An analysis of research articles that focused on the therapeutic effect of nanoformulations on skin cancer was included as part of the criteria for selecting the study. Nanoparticles have the potential to change the pharmacokinetics of the drug, increase the drug’s half-life by lowering immunogenicity, increase its bioavailability, decrease drug metabolism, and improve the solubility of poorly water-soluble drugs. The distribution of NP-based treatments to the skin requires special consideration due to the fact that the skin acts as both a physical and immunologic barrier. In addition, specialized technologies must take into consideration not only the target but also the channel of administration in order to be effective. The purpose of this review article was to provide an overview of many types of NPs, address the current landscape of NPs for skin cancer prevention and treatment, and provide a description of the application of NP-based technologies for drug delivery targeting the skin.

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应用纳米技术治疗皮肤癌的新方法

皮肤癌已成为全球第五大高发癌症，给经济和公共卫生带来了巨大挑战。在过去十年中，纳米粒子（NPs）作为一种针对皮肤癌的治疗方法的应用显著增加。这些信息是从 Scopus、Pubmed、Science Direct 和 Web of Science 等许多在线数据库中收集的，对侧重于纳米制剂对皮肤癌的治疗效果的研究文章进行分析是选择研究的标准之一。纳米颗粒有可能改变药物的药代动力学，通过降低免疫原性延长药物的半衰期，增加生物利用度，降低药物代谢，以及提高水溶性差的药物的溶解度。由于皮肤既是物理屏障，又是免疫屏障，因此需要特别考虑将基于 NP 的治疗分配到皮肤上。此外，专门的技术不仅要考虑目标，还要考虑给药渠道，这样才能有效。这篇综述文章的目的是概述多种类型的 NPs，探讨当前 NPs 在皮肤癌预防和治疗中的应用前景，并介绍基于 NP 的皮肤靶向给药技术的应用。

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来源期刊

Current Bioactive Compounds Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.90

自引率

0.00%

发文量

112

期刊介绍： The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.