Nebulization versus injection in ambulatory treatment of acute asthma: a comparative study

British journal of diseases of the chest Pub Date : 1988-01-01 DOI:10.1016/0007-0971(88)90087-3

Christer Janson, Merja Herala, Ingela Sjögren

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引用次数: 14

Abstract

Nebulization treatment of acute asthma with terbutaline and ipratropium bromide, given either separately with a 30-minute interval or combined as single inhalation, was compared with injection treatment with a combination of terbutaline given subcutaneously and theophylline given intravenously.

Seventy-seven episodes of acute asthma were studied. Nebulization treatment gave the same degree of bronchodilation as the injections, both immediately after treatment [measured as increase in forced expiratory volume in 1 second (FEV₁) in peak expiratory flow rate (PEFR) and improvement of dyspnoea] and during the following 6 days (measured by PEFR recordings at home).

The injection treatment caused a moderate increase in heart rate, whereas no circulatory side-effects were noted during nebulization treatment.

Administration of ipratropium bromide 30 minutes after terbutaline was not more effective than the combination of both substances as a single nebulization.

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雾化与注射在急性哮喘门诊治疗中的比较研究

用特布他林和异丙托溴铵雾化治疗急性哮喘，分别间隔30分钟或单次吸入，与特布他林皮下注射和茶碱静脉注射联合治疗进行比较。研究了77例急性哮喘发作。在治疗后立即(以呼气峰流速(PEFR) 1秒用力呼气量(FEV1)增加和呼吸困难改善来测量)和随后的6天(通过家中PEFR记录来测量)，雾化治疗的支气管扩张程度与注射治疗相同。注射治疗引起心率适度增加，而雾化治疗期间没有注意到循环副作用。在特布他林后30分钟给予异丙托溴铵并不比两种物质联合作为单一雾化更有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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British journal of diseases of the chest

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