CLINICAL EVALUATION OF ADJUNCTIVE ORAL SYSTEMIC VITAMIN E THERAPY IN PATIENTS WITH EROSIVE ORAL LICHEN PLANUS (A RANDOMIZED CONTROLLED CLINICALC TRIAL)

Abstract

BACKGROUND: Oral lichen planus (OLP) is a chronic autoimmune disorder. It mostly involves the skin, mucous membrane, and rarely the scalp and nails. It is an inflammatory condition driven by T-cells. Traditional treatment for OLP is topical steroids, which are frequently used to treat lesions with mild to moderate symptoms. Recent treatment modalities for oral lichen planus include micronutrients as antioxidants, including vitamin E, that modify the immune system function. AIM OF THE STUDY: The purpose of this study is to assess the clinical response to adjunctive oral systemic vitamin E therapy in erosive oral lichen planus patients. MATERIALS AND METHODS: 50 patients participated in this randomized, controlled clinical study. The erosive OLP patients were split into two parallel groups: 25 in group A, patients were administered oral systemic vitamin E adjunctive to topical corticosteroids. Group B: 25 patients received topical corticosteroids alone. Clinically, treatment responses were evaluated according to Thongprasom et al. scoring system before and after both treatment modalities. RESULTS: After 4 and 8 weeks of treatment, there was a significant decline in the Thongprasom scores in the research groups. Both the mean score values for the outcomes after four and eight weeks were more prominent in the test group. Throughout the clinical experiment, the test and control groups were statistically different. CONCLUSION: Systemic vitamin E adjunctive to topical corticosteroids has shown promising effects in the management of OLP with no side effects.