Melatonin improves nitric oxide bioavailability in isoproterenol induced myocardial injury

IF 3.8 3区医学 Q2 CELL BIOLOGY Molecular and Cellular Endocrinology Pub Date : 2024-05-24 DOI:10.1016/j.mce.2024.112279

Ramison Santos , Patrick Turck , Victor de Mello Palma , Fernanda Visioli , Vanessa Duarte Ortiz , Isabel Cristina Teixeira Proença , Tânia Regina G. Fernandes , Elissa Fernandes , Silvio Tasca , Cristina Campos Carraro , Adriane Belló-Klein , Alex Sander da Rosa Araujo , Neelam Khaper , Alexandre Luz de Castro

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Abstract

Isoproterenol administration is associated with cardiac inflammation and decreased NO availability. Melatonin has been reported to have cardioprotective effect. The aim of this study was to investigate the effect of melatonin on NO bioavailability and inflammation in myocardial injury induced by isoproterenol. Isoproterenol was administrated in male Wistar rats for 7 days to induce cardiac injury. The animals were divided into 3 groups: Control, Isoproterenol, Isoproterenol + Melatonin. Animals received melatonin for 7 days. Echocardiographic analysis was performed and the hearts were collected for molecular analysis. Animals that received isoproterenol demonstrated a reduction in left ventricle systolic and diastolic diameter, indicating the presence of concentric hypertrophy. Melatonin was able to attenuate this alteration. Melatonin also improved NO bioavailability and decreased NF-κβ, TNFα and IL-1β expression. In conclusion, melatonin exhibited a cardioprotective effect which was associated with improving NO bioavailability and decreasing the pro-inflammatory proteins.

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褪黑素可提高一氧化氮在异丙肾上腺素诱导的心肌损伤中的生物利用率

异丙肾上腺素与心脏炎症和氮氧化物供应减少有关。据报道，褪黑素具有保护心脏的作用。本研究旨在探讨褪黑素对异丙托品醇诱导的心肌损伤中 NO 生物利用率和炎症的影响。给雄性 Wistar 大鼠注射异丙肾上腺素 7 天以诱导心肌损伤。动物被分为 3 组：对照组、异丙肾上腺素组、异丙肾上腺素+褪黑素组。动物接受褪黑素治疗 7 天。进行超声心动图分析，并收集心脏进行分子分析。接受异丙肾上腺素治疗的动物显示左心室收缩和舒张直径缩小，表明存在同心性肥厚。褪黑素能够减轻这种变化。褪黑激素还改善了氮氧化物的生物利用率，降低了 NF-κβ、TNFα 和 IL-1β 的表达。总之，褪黑素具有保护心脏的作用，这与改善氮氧化物生物利用率和减少促炎蛋白有关。

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来源期刊

Molecular and Cellular Endocrinology 医学-内分泌学与代谢

CiteScore

9.00

自引率

2.40%

发文量

174

审稿时长

42 days

期刊介绍： Molecular and Cellular Endocrinology was established in 1974 to meet the demand for integrated publication on all aspects related to the genetic and biochemical effects, synthesis and secretions of extracellular signals (hormones, neurotransmitters, etc.) and to the understanding of cellular regulatory mechanisms involved in hormonal control.