Effects of acute stress on reward processing: A comprehensive meta-analysis of rodent and human studies

IF 4.3 2区 医学 Q1 NEUROSCIENCES Neurobiology of Stress Pub Date : 2024-05-24 DOI:10.1016/j.ynstr.2024.100647
Martino Schettino , Valeria Tarmati , Paola Castellano , Valeria Gigli , Luca Carnevali , Simona Cabib , Cristina Ottaviani , Cristina Orsini
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Abstract

Stressors can initiate a cascade of central and peripheral changes that modulate mesocorticolimbic dopaminergic circuits and, ultimately, behavioral response to rewards. Driven by the absence of conclusive evidence on this topic and the Research Domain Criteria framework, random-effects meta-analyses were adopted to quantify the effects of acute stressors on reward responsiveness, valuation, and learning in rodent and human subjects.

In rodents, acute stress reduced reward responsiveness (g = −1.43) and valuation (g = −0.32), while amplifying reward learning (g = 1.17). In humans, acute stress had marginal effects on valuation (g = 0.25), without affecting responsiveness and learning. Moderation analyses suggest that acute stress neither has unitary effects on reward processing in rodents nor in humans and that the duration of the stressor and specificity of reward experience (i.e., food vs drugs) may produce qualitatively and quantitatively different behavioral endpoints.

Subgroup analyses failed to reduce heterogeneity, which, together with the presence of publication bias, pose caution on the conclusions that can be drawn and point to the need of guidelines for the conduction of future studies in the field.

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急性应激对奖赏加工的影响:啮齿动物和人类研究的综合荟萃分析
压力可引发一系列中枢和外周变化,从而调节中皮质边缘多巴胺能回路,并最终影响对奖赏的行为反应。在啮齿类动物中,急性应激降低了奖赏反应性(g = -1.43 )和评价性(g = -0.32),同时扩大了奖赏学习(g = 1.17)。在人类中,急性应激对估价的影响微乎其微(g = 0.25),但不影响反应性和学习。调节分析表明,急性应激对啮齿类动物和人类的奖赏加工都没有单一的影响,应激持续时间和奖赏体验的特异性(即食物与药物)可能会产生不同质和量的行为终点。亚组分析未能减少异质性,再加上发表偏倚的存在,对可以得出的结论提出了警告,并指出需要为今后开展该领域的研究提供指导。
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来源期刊
Neurobiology of Stress
Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
9.40
自引率
4.00%
发文量
74
审稿时长
48 days
期刊介绍: Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.
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