The landscape of circRNAs in gliomas temozolomide resistance: Insights into molecular pathways

IF 5.9 3区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Non-coding RNA Research Pub Date : 2024-05-21 DOI:10.1016/j.ncrna.2024.05.010

Alireza Mafi , Neda Hedayati , Samaneh Kahkesh , Sara Khoshayand , Mina Alimohammadi , Najma Farahani , Kiavash Hushmandi

{"title":"The landscape of circRNAs in gliomas temozolomide resistance: Insights into molecular pathways","authors":"Alireza Mafi , Neda Hedayati , Samaneh Kahkesh , Sara Khoshayand , Mina Alimohammadi , Najma Farahani , Kiavash Hushmandi","doi":"10.1016/j.ncrna.2024.05.010","DOIUrl":null,"url":null,"abstract":"<div><p>As the deadliest type of primary brain tumor, gliomas represent a significant worldwide health concern. Circular RNA (circRNA), a unique non-coding RNA molecule, seems to be one of the most alluring target molecules involved in the pathophysiology of many kinds of cancers. CircRNAs have been identified as prospective targets and biomarkers for the diagnosis and treatment of numerous disorders, particularly malignancies. Recent research has established a clinical link between temozolomide (TMZ) resistance and certain circRNA dysregulations in glioma tumors. CircRNAs may play a therapeutic role in controlling or overcoming TMZ resistance in gliomas and may provide guidance for a novel kind of individualized glioma therapy. To address the biological characteristics of circRNAs and their potential to induce resistance to TMZ, this review has highlighted and summarized the possible roles that circRNAs may play in molecular pathways of drug resistance, including the Ras/Raf/ERK PI3K/Akt signaling pathway and metabolic processes in gliomas.</p></div>","PeriodicalId":37653,"journal":{"name":"Non-coding RNA Research","volume":"9 4","pages":"Pages 1178-1189"},"PeriodicalIF":5.9000,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468054024000970/pdfft?md5=d9e1b47113e6c1f5746ae1cbb7a1b6c0&pid=1-s2.0-S2468054024000970-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Non-coding RNA Research","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468054024000970","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

As the deadliest type of primary brain tumor, gliomas represent a significant worldwide health concern. Circular RNA (circRNA), a unique non-coding RNA molecule, seems to be one of the most alluring target molecules involved in the pathophysiology of many kinds of cancers. CircRNAs have been identified as prospective targets and biomarkers for the diagnosis and treatment of numerous disorders, particularly malignancies. Recent research has established a clinical link between temozolomide (TMZ) resistance and certain circRNA dysregulations in glioma tumors. CircRNAs may play a therapeutic role in controlling or overcoming TMZ resistance in gliomas and may provide guidance for a novel kind of individualized glioma therapy. To address the biological characteristics of circRNAs and their potential to induce resistance to TMZ, this review has highlighted and summarized the possible roles that circRNAs may play in molecular pathways of drug resistance, including the Ras/Raf/ERK PI3K/Akt signaling pathway and metabolic processes in gliomas.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

胶质瘤替莫唑胺耐药性中的 circRNAs 图谱：洞察分子途径

神经胶质瘤是最致命的原发性脑肿瘤，是全球关注的重大健康问题。环状 RNA（circRNA）是一种独特的非编码 RNA 分子，似乎是涉及多种癌症病理生理学的最诱人的靶分子之一。环状 RNA 已被确定为诊断和治疗多种疾病（尤其是恶性肿瘤）的前瞻性靶标和生物标志物。最近的研究确定了替莫唑胺（TMZ）耐药性与胶质瘤肿瘤中某些循环RNA失调之间的临床联系。循环RNA可能在控制或克服胶质瘤的TMZ耐药性方面发挥治疗作用，并为新型的胶质瘤个体化治疗提供指导。针对循环RNA的生物学特性及其诱导TMZ耐药性的潜力，本综述强调并总结了循环RNA在耐药性分子通路中可能发挥的作用，包括胶质瘤中的Ras/Raf/ERK PI3K/Akt信号通路和代谢过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Non-coding RNA Research Medicine-Biochemistry (medical)

CiteScore

7.70

自引率

6.00%

发文量

审稿时长

49 days

期刊介绍： Non-coding RNA Research aims to publish high quality research and review articles on the mechanistic role of non-coding RNAs in all human diseases. This interdisciplinary journal will welcome research dealing with all aspects of non-coding RNAs-their biogenesis, regulation and role in disease progression. The focus of this journal will be to publish translational studies as well as well-designed basic studies with translational and clinical implications. The non-coding RNAs of particular interest will be microRNAs (miRNAs), small interfering RNAs (siRNAs), small nucleolar RNAs (snoRNAs), U-RNAs/small nuclear RNAs (snRNAs), exosomal/extracellular RNAs (exRNAs), Piwi-interacting RNAs (piRNAs) and long non-coding RNAs. Topics of interest will include, but not limited to: -Regulation of non-coding RNAs -Targets and regulatory functions of non-coding RNAs -Epigenetics and non-coding RNAs -Biological functions of non-coding RNAs -Non-coding RNAs as biomarkers -Non-coding RNA-based therapeutics -Prognostic value of non-coding RNAs -Pharmacological studies involving non-coding RNAs -Population based and epidemiological studies -Gene expression / proteomics / computational / pathway analysis-based studies on non-coding RNAs with functional validation -Novel strategies to manipulate non-coding RNAs expression and function -Clinical studies on evaluation of non-coding RNAs The journal will strive to disseminate cutting edge research, showcasing the ever-evolving importance of non-coding RNAs in modern day research and medicine.