The Effectiveness of Aqueous Extract of Ginger on Some Sex Hormones and Biochemical Parameters in Female Laboratory Mice (Mus Musculus L.)

Abstract

Objective: Ginger is a flowering tropical plant that commonly used as a spice and flavoring having various pharmacological properties, several phytochemical compounds which has biological activity. The main bioactive compound in ginger is gingerol, have a powerful anti-inflammatory effect will greatly affect on fertility. Also, it has an effective role in many laboratory experiments to study the physiological activities of ginger extract on these functions. Aim: This study aimed to investigate the effects of ginger extract on some sex hormones like estrogen, progesterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in female mice, also its effect on total protein, albumin and globulin Methods: Thirty adult female mice of (Mus Musculus L.) weight (22-24g) were derived into three groups one control and two treated. Ginger water extract be ready to prepare with affecting doses according to experimental test on mice (3.5 and 7 mg body weight/mice). The concentration of serum female sex hormones (FSH, LH, progesterone and estrogen) were measured. Results: Ginger water extract caused a significant increase in the level of estrogen in both doses and significant increase in the level of FSH and LH in high dose only (P less than 0.01). While progesterone level show no significant changes. On the other hand, the serum total protein, albumin and globulin shows a significant increase only in total protein and globulin levels (P less than 0.01) in turn albumin level show no significant changes in comparison to control. Conclusion: The results of this study, ginger extract could increase the level of female sex hormones (estrogen, FSH and LH) and conceder as adjunctive natural therapy for improvement of female sex hormones as well as lead to increase in total protein and globulin level which is essential for boosting the immunity.