Evaluation of Paraoxonase, Arylesterase, Dipeptidyl Peptidase-IV, Oxidative Stress, and Oxidative DNA Damage in Patients with Obsessive-Compulsive Disorder

IF 0.5 4区医学 Q4 NEUROSCIENCES Neurochemical Journal Pub Date : 2024-05-24 DOI:10.1134/s1819712424010173

Eser Sağaltıcı, Hasan Belli, Aysegul Kirankaya, Hüseyin Köse, Cenk Ural, Mustafa Nuray Namlı, Onur Okan Demirci, Hasan Gökçay

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Abstract

Some findings have emerged from the field of oxidative stress in patients with psychiatric disorders. These date also state that oxidative balance and obsessive-compulsive disorder (OCD) are significantly related. Yet, researchers have not investigated oxidative stress, oxidative balance, and DNA damage together. We tested the levels of paraoxonase-1 (PON1), and arylesterase (ARE). We also tested the dipeptidyl peptidase-IV (DPP-IV), oxidative stress, and oxidative DNA damage. We enrolled 37 patients with OCD in the study. The diagnosis of OCD according to DSM-V criteria was established. Patients had not received treatment for at least 6 months. The controls were matched with the patients about sex, age, body mass index (BMI), and smoking. Clinicians used the sociodemographic information form. All subjects were evaluated with a semi-structured questionnaire. Serum PON1, ARE, DPP-IV, oxidative stress index (OSI), and 8‑hydroxideoxiguanosine (8-OHdG) calculations were conducted in the biochemical laboratory. PON1 and DPP-IV levels were not different between OCD patients and the control group (P > 0.05). An oxidative DNA damage marker 8-OHdG—and OSI were higher in the patient’s group (p < 0.05). But levels of ARE were significantly lower in OCD patients (P < 0.05). We found evidence that oxidative stress-induced parameters such as OSI, ARE, and 8-OHdG might be related to a specific pathologic state in patients with OCD. The findings may provide a rationale for treating the pathological processes.

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评估强迫症患者体内的副氧自由基酶、芳酯酶、二肽基肽酶-IV、氧化应激和 DNA 氧化损伤

摘要在精神病患者的氧化应激领域出现了一些研究结果。这些研究结果还表明，氧化平衡与强迫症（OCD）有很大关系。然而，研究人员尚未将氧化应激、氧化平衡和 DNA 损伤结合起来进行研究。我们检测了副氧合酶-1（PON1）和芳基酯酶（ARE）的水平。我们还检测了二肽基肽酶-IV（DPP-IV）、氧化应激和氧化性 DNA 损伤。我们在研究中招募了 37 名强迫症患者。根据 DSM-V 标准确定了强迫症的诊断。患者至少在 6 个月内未接受过治疗。对照组在性别、年龄、体重指数（BMI）和吸烟方面与患者匹配。临床医生使用社会人口信息表。所有受试者均接受了半结构式问卷调查。生化实验室对血清 PON1、ARE、DPP-IV、氧化应激指数（OSI）和 8-hydroxideoxiguanosine (8-OHdG) 进行了计算。PON1 和 DPP-IV 水平在强迫症患者和对照组之间没有差异（P > 0.05）。患者组的氧化 DNA 损伤标志物 8-OHdG 和 OSI 较高（P < 0.05）。但强迫症患者的 ARE 水平明显较低（P< 0.05）。我们发现有证据表明，氧化应激引起的参数，如 OSI、ARE 和 8-OHdG 可能与强迫症患者的特定病理状态有关。这些发现可能为治疗病理过程提供了理论依据。

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来源期刊

Neurochemical Journal 医学-神经科学

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components. The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.