Patterns of Changes in Certain Neurospecific Proteins in Patients with Chronic Mercury Intoxication in Post-Contact Period

IF 0.5 4区 医学 Q4 NEUROSCIENCES Neurochemical Journal Pub Date : 2024-05-24 DOI:10.1134/s1819712424010033
G. M. Bodienkova, E. V. Boklazhenko
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Abstract—The aim of the study was to identify patterns of change in certain neurospecific proteins (BDNF, S100β, MBP) in the serum of patients with chronic mercury intoxication after stopping exposure to the toxicant. In clinical conditions, men with an established diagnosis of chronic mercury intoxication (CMI) were examined in a distant period after isolation from a toxicant in chemical production. Serum concentrations of neurospecific proteins (BDNF, S100β, MBP) were determined by solid-phase enzyme-linked immunosorbent assay using a commercial test-systems of ChemiKine (United States), CanAg (Sweden), and AnshLabs (United States), respectively. The obtained results indicate and confirm the progression of the disease in the distant, post-exposure period of chronic mercury intoxication, which corresponds to the clinical manifestation of the disease. Elevated serum concentrations of BDNF, S100β protein, and MBP were reported in patients with CMI 5 years after exposure to the toxicant. Long-lasting high levels of neurotrophic proteins may reflect the course of neurodestructive processes occurring in the nervous tissue and the progression of the disease. BDNF deficiency in CMI individuals examined in a linked sample at 8 years post-exposure may be indicative of attenuation of neurogenesis. Further studies will contribute to a more accurate definition and understanding of the use of serum concentrations of BDNF, S100β protein, MBP as markers of pathological process activity and a specific target for effective treatment.

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接触后慢性汞中毒患者某些神经特异性蛋白质的变化模式
摘要--该研究旨在确定慢性汞中毒患者在停止接触毒物后血清中某些神经特异性蛋白(BDNF、S100β、MBP)的变化规律。在临床条件下,我们对已确诊为慢性汞中毒(CMI)的男性患者在与化工生产中的有毒物质隔离后的一段较长时期内进行了检查。分别使用 ChemiKine(美国)、CanAg(瑞典)和 AnshLabs(美国)的商用测试系统,通过固相酶联免疫吸附法测定了血清中神经特异性蛋白质(BDNF、S100β、MBP)的浓度。所得结果表明并证实,在慢性汞中毒暴露后的远期,即与疾病临床表现相对应的时期,疾病正在发展。据报道,在接触有毒物质 5 年后,慢性汞中毒患者血清中的 BDNF、S100β 蛋白和 MBP 浓度升高。神经营养蛋白的长期高水平可能反映了神经组织中发生的神经损伤过程和疾病的进展。在接触毒物 8 年后的关联样本中,CMI 患者体内缺乏 BDNF,这可能表明神经发生衰减。进一步的研究将有助于更准确地定义和理解血清中 BDNF、S100β 蛋白和 MBP 的浓度,将其作为病理过程活动的标记和有效治疗的特定目标。
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来源期刊
Neurochemical Journal
Neurochemical Journal 医学-神经科学
自引率
20.00%
发文量
40
审稿时长
>12 weeks
期刊介绍: Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components. The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.
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