Biology's transformation: from observation through experiment to computation.

IF 2.4 Q2 MATHEMATICAL & COMPUTATIONAL BIOLOGY Bioinformatics advances Pub Date : 2024-05-22 eCollection Date: 2024-01-01 DOI:10.1093/bioadv/vbae069
Christos A Ouzounis
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Abstract

Summary: We explore the nuanced temporal and epistemological distinctions among natural sciences, particularly the contrasting treatment of time and the interplay between theory and experimentation. Physics, an exemplar of mature science, relies on theoretical models for predictability and simulations. In contrast, biology, traditionally experimental, is witnessing a computational surge, with data analytics and simulations reshaping its research paradigms. Despite these strides, a unified theoretical framework in biology remains elusive. We propose that contemporary global challenges might usher in a renewed emphasis, presenting an opportunity for the establishment of a novel theoretical underpinning for the life sciences.

Availability and implementation: https://github.com/ouzounis/CLS-emerges Data in Json format, Images in PNG format.

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生物学的转变:从观察到实验再到计算。
摘要:我们探讨了自然科学之间细微的时间和认识论区别,特别是对时间的不同处理以及理论与实验之间的相互作用。物理学是成熟科学的典范,它依赖理论模型来实现可预测性和模拟。与此相反,传统上以实验为基础的生物学,却在计算方面突飞猛进,数据分析和模拟重塑了其研究范式。尽管取得了这些进展,但生物学中的统一理论框架仍未形成。我们认为,当代的全球性挑战可能会带来新的重点,为建立生命科学的新理论基础提供了机会。可用性和实施:https://github.com/ouzounis/CLS-emerges Json 格式的数据,PNG 格式的图像。
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