Role of miRNAs in macrophage-mediated kidney injury.

IF 2.6 3区医学 Q1 PEDIATRICS Pediatric Nephrology Pub Date : 2024-12-01 Epub Date: 2024-05-27 DOI:10.1007/s00467-024-06414-5

Junxin Li, Xida Yan, Zhigui Wu, Jing Shen, Yalin Li, Yueshui Zhao, Fukuan Du, Mingxing Li, Xu Wu, Yu Chen, Zhangang Xiao, Shurong Wang

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Abstract

Macrophages, crucial components of the human immune system, can be polarized into M1/M2 phenotypes, each with distinct functions and roles. Macrophage polarization has been reported to be significantly involved in the inflammation and fibrosis observed in kidney injury. MicroRNA (miRNA), a type of short RNA lacking protein-coding function, can inhibit specific mRNA by partially binding to its target mRNA. The intricate association between miRNAs and macrophages has been attracting increasing interest in recent years. This review discusses the role of miRNAs in regulating macrophage-mediated kidney injury. It shows how miRNAs can influence macrophage polarization, thereby altering the biological function of macrophages in the kidney. Furthermore, this review highlights the significance of miRNAs derived from exosomes and extracellular vesicles as a crucial mediator in the crosstalk between macrophages and kidney cells. The potential of miRNAs as treatment applications and biomarkers for macrophage-mediated kidney injury is also discussed.

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miRNA 在巨噬细胞介导的肾损伤中的作用

巨噬细胞是人体免疫系统的重要组成部分，可极化为 M1/M2 表型，各自具有不同的功能和作用。据报道，巨噬细胞的极化与肾损伤中观察到的炎症和纤维化密切相关。微小 RNA（miRNA）是一种缺乏蛋白质编码功能的短 RNA，可通过与目标 mRNA 的部分结合来抑制特定的 mRNA。近年来，miRNA 与巨噬细胞之间错综复杂的联系引起了越来越多的关注。本综述讨论了 miRNA 在调节巨噬细胞介导的肾损伤中的作用。它展示了 miRNA 如何影响巨噬细胞的极化，从而改变巨噬细胞在肾脏中的生物功能。此外，这篇综述还强调了源自外泌体和细胞外囊泡的 miRNA 作为巨噬细胞与肾脏细胞之间串联的关键介质的重要性。本文还讨论了 miRNAs 作为巨噬细胞介导的肾损伤的治疗应用和生物标志物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Nephrology 医学-泌尿学与肾脏学

CiteScore

4.70

自引率

20.00%

发文量

465

审稿时长

1 months

期刊介绍： International Pediatric Nephrology Association Pediatric Nephrology publishes original clinical research related to acute and chronic diseases that affect renal function, blood pressure, and fluid and electrolyte disorders in children. Studies may involve medical, surgical, nutritional, physiologic, biochemical, genetic, pathologic or immunologic aspects of disease, imaging techniques or consequences of acute or chronic kidney disease. There are 12 issues per year that contain Editorial Commentaries, Reviews, Educational Reviews, Original Articles, Brief Reports, Rapid Communications, Clinical Quizzes, and Letters to the Editors.