Anti-inflammatory and immunomodulatory effects of mesenchymal stem cell therapy on parasitic drug resistance.

IF 4.2 2区 医学 Q1 INFECTIOUS DISEASES Expert Review of Anti-infective Therapy Pub Date : 2024-06-01 Epub Date: 2024-05-31 DOI:10.1080/14787210.2024.2360684
Soheil Sadr, Pouria Ahmadi Simab, Mahta Niazi, Zahra Yousefsani, Narges Lotfalizadeh, Ashkan Hajjafari, Hassan Borji
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Abstract

Introduction: The emergence of antiparasitic drug resistance poses a concerning threat to animals and humans. Mesenchymal Stem Cells (MSCs) have been widely used to treat infections in humans, pets, and livestock. Although this is an emerging field of study, the current review outlines possible mechanisms and examines potential synergism in combination therapies and the possible harmful effects of such an approach.

Areas covered: The present study delved into the latest pre-clinical research on utilizing MSCs to treat parasitic infections. As per investigations, the introduction of MSCs to patients grappling with parasitic diseases like schistosomiasis, malaria, cystic echinococcosis, toxoplasmosis, leishmaniasis, and trypanosomiasis has shown a reduction in parasite prevalence. This intervention also alters the levels of both pro- and anti-inflammatory cytokines. Furthermore, the combined administration of MSCs and antiparasitic drugs has demonstrated enhanced efficacy in combating parasites and modulating the immune response.

Expert opinion: Mesenchymal stem cells are a potential solution for addressing parasitic drug resistance. This is mainly because of their remarkable immunomodulatory abilities, which can potentially help combat parasites' resistance to drugs.

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间充质干细胞疗法对寄生虫抗药性的抗炎和免疫调节作用。
导言:抗寄生虫药物耐药性的出现对动物和人类构成了威胁。间充质干细胞(MSCs)已被广泛用于治疗人类、宠物和牲畜的感染。虽然这是一个新兴的研究领域,但目前的综述概述了可能的机制,研究了联合疗法中潜在的协同作用以及这种方法可能产生的有害影响:本研究深入探讨了利用间充质干细胞治疗寄生虫感染的最新临床前研究。根据调查,为血吸虫病、疟疾、囊性棘球蚴病、弓形虫病、利什曼病和锥虫病等寄生虫病患者引入间充质干细胞后,寄生虫感染率有所下降。这种干预措施还能改变促炎和抗炎细胞因子的水平。此外,间充质干细胞和抗寄生虫药物的联合用药在对抗寄生虫和调节免疫反应方面的疗效也得到了增强:间充质干细胞是解决寄生虫抗药性问题的潜在方案。专家观点:间充质干细胞是解决寄生虫抗药性问题的潜在方案,这主要是因为间充质干细胞具有显著的免疫调节能力,可帮助消除寄生虫的抗药性。
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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
66
审稿时长
4-8 weeks
期刊介绍: Expert Review of Anti-Infective Therapy (ISSN 1478-7210) provides expert reviews on therapeutics and diagnostics in the treatment of infectious disease. Coverage includes antibiotics, drug resistance, drug therapy, infectious disease medicine, antibacterial, antimicrobial, antifungal and antiviral approaches, and diagnostic tests.
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