Zn-Mediated Fragmentation of N-Alkoxyphthalimides Enabling the Synthesis of gem-Difluoroalkenes

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2024-05-28 DOI:10.1021/acs.orglett.4c01433

Yi-Yue Wang, Wei-Jun Pang, Tie Liu, Jing Sun* and Ming-Dong Zhou*,

引用次数: 0

Abstract

Zn-mediated generation of alkoxyl radicals from N-alkoxyphthalimides emerged as an efficient approach for forming diverse and valuable alkyl radicals through β-scission or a hydrogen atom transfer process. The alkyl radical species can be further trapped by α-trifluoromethyl alkenes to construct a series of gem-difluoroalkenes.

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Zn 介导的 N-烷氧基邻苯二甲酰亚胺碎裂促进了 gem-Difluoroalkenes 的合成。

Zn 介导的 N-烷氧基邻苯二甲酰亚胺生成烷氧基自由基是一种有效的方法，可通过 β 裂解或氢原子转移过程形成多种有价值的烷基自由基。烷基自由基物种可进一步被 α-三氟甲基烯烃捕获，从而构建出一系列 gem-二氟烯烃。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.