Salvia hispanica L. (chia) seed improves redox state and reverts extracellular matrix collagen deposition in skeletal muscle of sucrose-rich diet-fed rats.

IF 5 3区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY BioFactors Pub Date : 2024-05-28 DOI:10.1002/biof.2087
Paola G Illesca, María Del R Ferreira, Adriana Benmelej, María Eugenia D'Alessandro
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Abstract

Skeletal muscle (SkM) is a plastic and dynamic tissue, essential in energy metabolism. Growing evidence suggests a close relationship between intramuscular fat accumulation, oxidative stress (OS), extracellular matrix (ECM) remodeling, and metabolic deregulation in SkM. Nowadays natural products emerge as promising alternatives for the treatment of metabolic disorders. We have previously shown that chia seed administration reverts SkM lipotoxicity and whole-body insulin resistant (IR) in sucrose-rich diet (SRD) fed rats. The purpose of the present study was to assess the involvement of OS and fibrosis in SkM metabolic impairment of insulin-resistant rats fed a long-term SRD and the effects of chia seed upon these mechanisms as therapeutic strategy. Results showed that insulin-resistant SRD-fed rats exhibited sarcopenia, increase in lipid peroxidation, altered redox state, and ECM remodeling-increased collagen deposition and lower activity of the metalloproteinase 2 (MMP-2) in SkM. Chia seed increased ferric ion reducing antioxidant power and glutathione reduced form levels, and the activities of glutathione peroxidase and glutathione reductase enzymes. Moreover, chia seed reversed fibrosis and restored the MMP-2 activity. This work reveals a participation of the OS and ECM remodeling in the metabolic alterations of SkM in our experimental model. Moreover, current data show novel properties of chia seed with the potential to attenuate SkM OS and fibrosis, hallmark of insulin-resistant muscle.

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丹参籽可改善富含蔗糖饮食的大鼠骨骼肌的氧化还原状态并逆转细胞外基质胶原沉积。
骨骼肌(SkM)是一种可塑的动态组织,对能量代谢至关重要。越来越多的证据表明,肌肉内脂肪堆积、氧化应激(OS)、细胞外基质(ECM)重塑和骨骼肌代谢失调之间存在密切关系。如今,天然产品已成为治疗代谢紊乱的有前途的替代品。我们曾研究表明,服用奇异籽可恢复富含蔗糖饮食(SRD)喂养大鼠的胰岛素抵抗(IR)。本研究的目的是评估 OS 和纤维化在长期 SRD 喂养的胰岛素抵抗大鼠 SkM 代谢损伤中的参与作用,以及奇异籽作为治疗策略对这些机制的影响。结果表明,胰岛素耐受性 SRD 大鼠表现出肌肉疏松、脂质过氧化增加、氧化还原状态改变和 ECM 重塑--SkM 中胶原沉积增加和金属蛋白酶 2(MMP-2)活性降低。奇异籽提高了铁离子还原型抗氧化能力和谷胱甘肽还原型水平,以及谷胱甘肽过氧化物酶和谷胱甘肽还原酶的活性。此外,奇异籽还能逆转纤维化并恢复 MMP-2 的活性。这项工作揭示了在我们的实验模型中,OS 和 ECM 重塑参与了 SkM 的代谢改变。此外,目前的数据还显示了奇异籽的新特性,它有可能减轻胰岛素抵抗肌肉的标志--SkM OS 和纤维化。
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来源期刊
BioFactors
BioFactors 生物-内分泌学与代谢
CiteScore
11.50
自引率
3.30%
发文量
96
审稿时长
6-12 weeks
期刊介绍: BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease. The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements. In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.
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