Risk factors and disease associations in people living with idiopathic intracranial hypertension.

IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY Expert Review of Neurotherapeutics Pub Date : 2024-07-01 Epub Date: 2024-05-27 DOI:10.1080/14737175.2024.2359420
Olivia Potter, Vaishnavi Menon, Susan P Mollan
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Abstract

Introduction: Idiopathic intracranial hypertension is a neurological condition characterized by a raised intracranial pressure and papilledema, leading to chronic headaches and visual disturbances. By recognizing modifiable risk factors and deploying evidence-based interventions, healthcare providers have the potential to mitigate the burden of the disease and improve patient outcomes.

Areas covered: It is well known that the condition occurs in predominantly pre-menopausal females who live with obesity particularly in the context of recent weight gain. This review discusses what risk factors may contribute to the metabolic underpinnings of cerebrospinal fluid dysregulation. There are a number of disease associations that are important to screen for as they can alter management.

Expert opinion: There is emerging evidence to suggest that idiopathic intracranial hypertension is a systemic metabolic disease and it is unknown what are all the risk factors are that precipitate the condition. Targeting certain hardwired risk factors is unachievable. However, as recent weight gain has been identified as a predominant risk factor for the development of the disease and relapse, modification of body weight should be the primary aim of management. Insightful research into the involvement of the neuroendocrine axis driving cerebrospinal fluid dysregulation now has the potential for the development of therapeutic targets.

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特发性颅内高压患者的风险因素和疾病关联。
简介特发性颅内高压是一种神经系统疾病,其特点是颅内压升高和乳头水肿,导致慢性头痛和视力障碍。通过识别可改变的风险因素并采取循证干预措施,医疗服务提供者有可能减轻该疾病的负担并改善患者的预后:众所周知,这种疾病主要发生在绝经前女性中,她们生活在肥胖的环境中,尤其是在近期体重增加的情况下。这篇综述讨论了哪些风险因素可能会导致脑脊液失调的代谢基础。专家认为,有一些疾病相关因素需要进行筛查,因为它们可能会改变治疗方法:有新证据表明,特发性颅内高压是一种全身性代谢疾病,而诱发这种疾病的风险因素尚不清楚。针对某些固有的危险因素是不可能实现的。然而,由于近期体重增加已被确定为该病发病和复发的主要风险因素,因此,控制体重应成为治疗的首要目标。目前,对神经内分泌轴参与脑脊液失调的深入研究有望开发出治疗靶点。
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来源期刊
Expert Review of Neurotherapeutics
Expert Review of Neurotherapeutics Medicine-Neurology (clinical)
CiteScore
7.00
自引率
2.30%
发文量
61
审稿时长
4-8 weeks
期刊介绍: Expert Review of Neurotherapeutics (ISSN 1473-7175) provides expert reviews on the use of drugs and medicines in clinical neurology and neuropsychiatry. Coverage includes disease management, new medicines and drugs in neurology, therapeutic indications, diagnostics, medical treatment guidelines and neurological diseases such as stroke, epilepsy, Alzheimer''s and Parkinson''s. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points
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