Biological ultrathin amniotic membrane flap to close refractory macular holes associated with high myopia.

IF 2.4 3区医学 Q2 OPHTHALMOLOGY Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-05-28 DOI:10.1007/s00417-024-06509-7

Yuanyuan Fan, Jiagui Wang, Jie Lei, Jiangdong Ji, Ping Xie, Zizhong Hu

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Abstract

Purpose: To propose an ultrathin biological amniotic membrane (btAM) thinner than 10 μm as the graft to treat highly myopic macular holes (MH).

Methods: This pilot study included 14 patients affected by refractory macular holes associated with high myopia. btAM was used as a bandage covering the holes. The best-corrected visual acuity (BCVA), fundus photography, and optical coherence tomography (OCT) before and after surgery were compared.

Results: The mean MH size was 865.93 ± 371.72 μm and all the MHs achieved anatomical closure. The btAM located centrally and fully on MHs from fundus photography yet no obvious visual masking was complained. The average BCVA 1 month, 3, and 6 months after surgery were 0.95 ± 0.24, 0.92 ± 0.23, 0.92 ± 0.23 logMAR, respectively, improved significantly compared to pre-operative BCVA (1.24 ± 0.42 logMAR, all P < 0.05). Ten out of 14 (71.4%) exhibited 2C closure patterns (formally closed and no bare RPE) on OCT.

Conclusion: The btAM thinner showed a favorable anatomical success with less risk of parafoveal atrophy or iatrogenic injuries and shortened the dissolving time.

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用生物超薄羊膜瓣关闭与高度近视有关的难治性黄斑孔。

目的：提议用厚度小于 10 μm 的超薄生物羊膜（btAM）作为治疗高度近视黄斑孔（MH）的移植物：这项试验研究包括14名患有高度近视相关难治性黄斑孔的患者。比较了手术前后的最佳矫正视力（BCVA）、眼底照相和光学相干断层扫描（OCT）：平均 MH 大小为 865.93 ± 371.72 μm，所有 MH 均达到解剖闭合。从眼底照片来看，btAM位于MHs的中心位置且完全闭合，但没有明显的视觉遮挡。术后1个月、3个月和6个月的平均BCVA分别为0.95±0.24、0.92±0.23和0.92±0.23 logMAR，与术前BCVA（1.24±0.42 logMAR，均为P）相比有显著改善：btAM稀释剂在解剖学上取得了良好的效果，降低了眼底萎缩或先天性损伤的风险，并缩短了溶解时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Graefe’s Archive for Clinical and Experimental Ophthalmology 医学-眼科学

CiteScore

5.40

自引率

7.40%

发文量

398

审稿时长

3 months

期刊介绍： Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.