Distribution and predictors of F-18-FDG uptake values of non-malignant cervical lymph nodes in pediatric patients.

IF 3.1 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING EJNMMI Research Pub Date : 2024-05-29 DOI:10.1186/s13550-024-01110-9

Jeremy Godefroy, Raphael Godefroy, Koral Vedder, Yair Altura, Alexandre Chicheportiche, Simona Ben-Haim, Gal Goldstein

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Abstract

Background: F-18-flurodeoxyglucose (FDG) PET/CT is routinely used for staging, evaluation of response to treatment and follow-up of most pediatric malignancies. Cervical lymph nodes can be involved in some pediatric malignancies, but increased uptake in non-malignant cervical lymph nodes is not exceptional in this population. The aim of the present study is to identify predictors of the maximum uptake in non-malignant cervical lymph nodes in the pediatric population.

Methods: 191 FDG PET/CT studies of pediatric patients without malignant involvement of cervical lymph nodes were retrospectively reviewed. The maximal Standard Uptake Value in the hottest cervical lymph node (SUVmax_CLN), as well as demographic, technical and imaging variables were recorded. The predictive effect of those variables on SUVmax_CLN was estimated using linear regression models.

Results: Increased FDG activity in cervical nodes was observed in 136/191 studies (71%). The mean SUVmax_CLN was 2.2 ± 1.3. Ipsilateral palatine tonsil SUVmax, mean liver uptake, and treatment status were all statistically significant predictors of SUVmax_CLN. However, in multivariate regression analysis, only ipsilateral palatine tonsil SUVmax was found to be significant. In addition, SUVmax_CLN was greater than the mean liver uptake in 50% of all studies. This proportion was higher in younger children, reaching 77% of studies of children younger than six years.

Conclusion: SUVmax in ipsilateral palatine tonsil is a strong predictor of the maximal uptake value of non-malignant cervical lymph nodes in children. The intensity of uptake in non-malignant cervical lymph nodes is frequently higher than liver uptake in children, and this tendency increases for younger patients.

Trial was registered: In the internal hospital registry under TRN 0209-22-HMO on date 23.04.2022.

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儿科非恶性颈淋巴结 F-18-FDG 摄取值的分布和预测因素。

背景：F-18-氟脱氧葡萄糖（FDG）正电子发射计算机断层扫描（PET/CT）被常规用于大多数儿科恶性肿瘤的分期、治疗反应评估和随访。某些儿科恶性肿瘤可能累及颈淋巴结，但非恶性颈淋巴结摄取增加在这一人群中并不罕见。本研究旨在确定儿科非恶性颈淋巴结最大摄取值的预测因素。方法：对191例未恶性累及颈淋巴结的儿科患者的FDG PET/CT研究进行了回顾性回顾。记录了最热颈部淋巴结的最大标准摄取值（SUVmaxCLN）以及人口统计学、技术和成像变量。利用线性回归模型估算了这些变量对 SUVmaxCLN 的预测作用：结果：136/191 项研究（71%）观察到宫颈结节中 FDG 活性增加。平均 SUVmaxCLN 为 2.2 ± 1.3。同侧腭扁桃体SUVmax、肝脏平均摄取量和治疗状态都是SUVmaxCLN的统计学显著预测因素。然而，在多变量回归分析中，只有同侧腭扁桃体 SUVmax 具有显著性。此外，在所有研究中，50% 的研究发现 SUVmaxCLN 大于肝脏平均摄取量。这一比例在年龄较小的儿童中更高，在对 6 岁以下儿童的研究中达到 77%：结论：同侧腭扁桃体的 SUVmax 是预测儿童非恶性颈淋巴结最大摄取值的有力指标。在儿童中，非恶性颈淋巴结的摄取强度往往高于肝脏摄取，而且这种趋势在年龄较小的患者中会加剧：医院内部登记：TRN 0209-22-HMO，日期为 2022 年 4 月 23 日。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

EJNMMI Research RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING&nb-

CiteScore

5.90

自引率

3.10%

发文量

审稿时长

13 weeks

期刊介绍： EJNMMI Research publishes new basic, translational and clinical research in the field of nuclear medicine and molecular imaging. Regular features include original research articles, rapid communication of preliminary data on innovative research, interesting case reports, editorials, and letters to the editor. Educational articles on basic sciences, fundamental aspects and controversy related to pre-clinical and clinical research or ethical aspects of research are also welcome. Timely reviews provide updates on current applications, issues in imaging research and translational aspects of nuclear medicine and molecular imaging technologies. The main emphasis is placed on the development of targeted imaging with radiopharmaceuticals within the broader context of molecular probes to enhance understanding and characterisation of the complex biological processes underlying disease and to develop, test and guide new treatment modalities, including radionuclide therapy.