Prognostic significance of ASXL1 mutations in acute myeloid leukemia: A systematic review and meta-analysis.

Pub Date : 2024-01-01 DOI:10.22088/cjim.15.2.202

Maryam Sheikhi, Mehrdad Rostami, Gordon Ferns, Hossein Ayatollahi, Payam Siyadat, Yasamin Ayatollahi, Zahra Khoshnegah

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Abstract

Background: Although genetic mutations in additional sex-combs-like 1 (ASXL1) are prevalent in acute myeloid leukemia (AML), their exact impact on the AML prognosis remains uncertain. Hence, the present article was carried out to explore the prognostic importance of ASXL1 mutations in AML.

Methods: We thoroughly searched electronic scientific databases to find eligible papers. Twenty-seven studies with an overall number of 8,953 participants were selected for the current systematic review. The hazard ratio (HR) and 95% confidence interval (CI) for overall survival (OS), event-free survival (EFS), and relapse-free survival (RFS) were extracted from all studies with multivariate or univariate analysis. Pooled HRs and p-values were also calculated as a part of our work.

Results: The pooled HR for OS in multivariable analysis indicated that ASXL1 significantly diminished survival in AML patients (pooled HR: 1.67; 95% CI: 1.342-2.091).

Conclusions: ASXL1 mutations may confer a poor prognosis in AML. Hence, they may be regarded as potential prognostic factors. However, more detailed studies with different ASXL1 mutations are suggested to shed light on this issue.

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急性髓性白血病 ASXL1 基因突变的预后意义：系统综述与荟萃分析。

背景：尽管附加性染色体样1（ASXL1）基因突变在急性髓性白血病（AML）中很常见，但它们对AML预后的确切影响仍不确定。因此，本文旨在探讨ASXL1基因突变对AML预后的重要性：我们全面检索了电子科学数据库，以找到符合条件的论文。方法：我们彻底检索了电子科学数据库，找到了符合条件的论文，并选择了27项研究（总人数为8953人）进行本次系统综述。通过多变量或单变量分析，从所有研究中提取了总生存期（OS）、无事件生存期（EFS）和无复发生存期（RFS）的危险比（HR）和95%置信区间（CI）。作为我们工作的一部分，我们还计算了汇总的HRs和P值：结果：多变量分析中OS的汇总HR表明，ASXL1会显著降低AML患者的生存率（汇总HR：1.67；95% CI：1.342-2.091）：结论：ASXL1突变可能导致急性髓细胞白血病患者预后不良。结论：ASXL1突变可能会导致急性髓细胞性白血病预后不良，因此可将其视为潜在的预后因素。不过，建议对不同的ASXL1突变进行更详细的研究，以揭示这一问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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