The Potential Role of Intestinal Stem Cells and Microbiota for the Treatment of Colorectal Cancer.

4区医学 Q2 Biochemistry, Genetics and Molecular Biology Advances in experimental medicine and biology Pub Date : 2024-05-30 DOI:10.1007/5584_2024_803

Babak Arjmand, Sepideh Alavi-Moghadam, Zahra Faraji, Morteza Aghajanpoor-Pasha, Hasan Jalaeikhoo, Mohsen Rajaeinejad, Mohsen Nikandish, Ali Faridfar, Ahmad Rezazadeh-Mafi, Mostafa Rezaei-Tavirani, Arsalan Irompour

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Abstract

Colorectal cancer is a global health concern with high incidence and mortality rates. Conventional treatments like surgery, chemotherapy, and radiation therapy have limitations in improving patient survival rates. Recent research highlights the role of gut microbiota and intestinal stem cells in maintaining intestinal health and their potential therapeutic applications in colorectal cancer treatment. The interaction between gut microbiota and stem cells influences epithelial self-renewal and overall intestinal homeostasis. Novel therapeutic approaches, including immunotherapy, targeted therapy, regenerative medicine using stem cells, and modulation of gut microbiota, are being explored to improve treatment outcomes. Accordingly, this chapter provides an overview of the potential therapeutic applications of gut microbiota and intestinal stem cells in treating colorectal cancer.

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肠干细胞和微生物群在治疗结直肠癌中的潜在作用

大肠癌是全球关注的健康问题，发病率和死亡率都很高。手术、化疗和放疗等传统治疗方法在提高患者生存率方面存在局限性。最新研究强调了肠道微生物群和肠干细胞在维持肠道健康方面的作用，以及它们在结直肠癌治疗中的潜在治疗应用。肠道微生物群和干细胞之间的相互作用影响着上皮细胞的自我更新和整体肠道平衡。目前正在探索新的治疗方法，包括免疫疗法、靶向疗法、利用干细胞的再生医学以及调节肠道微生物群，以改善治疗效果。因此，本章概述了肠道微生物群和肠干细胞在治疗结直肠癌方面的潜在治疗应用。

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来源期刊

Advances in experimental medicine and biology 医学-医学：研究与实验

CiteScore

5.90

自引率

0.00%

发文量

465

审稿时长

2-4 weeks

期刊介绍： Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.