Pain-Insomnia-Depression Syndrome: Triangular Relationships, Pathobiological Correlations, Current Treatment Modalities, and Future Direction.

IF 4.1 2区 医学 Q1 CLINICAL NEUROLOGY Pain and Therapy Pub Date : 2024-08-01 Epub Date: 2024-05-30 DOI:10.1007/s40122-024-00614-5
Murtaza Haidary, Shamim Arif, Dawood Hossaini, Shekiba Madadi, Elham Akbari, Hossain Rezayee
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Abstract

Pain-insomnia-depression syndrome (PIDS) is a complex triad of chronic pain, insomnia, and depression that has profound effects on an individual's quality of life and mental health. The pathobiological context of PIDS involves complex neurobiological and physiological mechanisms, including alterations in neurotransmitter systems and impaired pain processing pathways. The first-line therapeutic approaches for the treatment of chronic pain, depression, and insomnia are a combination of pharmacological and non-pharmacological therapies. In cases where patients do not respond adequately to these treatments, additional interventions such as deep brain stimulation (DBS) may be required. Despite advances in understanding and treatment, there are still gaps in knowledge that need to be addressed. To improve our understanding, future research should focus on conducting longitudinal studies to uncover temporal associations, identify biomarkers and genetic markers associated with PIDS, examine the influence of psychosocial factors on treatment responses, and develop innovative interventions that address the complex nature of PIDS. The aim of this study is to provide a comprehensive overview of these components and to discuss their underlying pathobiological relationships.

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疼痛-失眠-抑郁综合征:三角关系、病理生物学相关性、当前治疗模式和未来方向。
疼痛-失眠-抑郁综合征(PIDS)是慢性疼痛、失眠和抑郁的复杂三联征,对患者的生活质量和心理健康有着深远的影响。PIDS 的病理生物学背景涉及复杂的神经生物学和生理学机制,包括神经递质系统的改变和疼痛处理通路的受损。治疗慢性疼痛、抑郁和失眠的一线疗法是药物疗法和非药物疗法的结合。如果患者对这些疗法反应不佳,则可能需要额外的干预措施,如深部脑刺激(DBS)。尽管在认识和治疗方面取得了进步,但仍有一些知识空白需要填补。为了提高我们的认识,未来的研究应侧重于开展纵向研究以揭示时间上的关联,确定与 PIDS 相关的生物标记物和遗传标记物,研究心理社会因素对治疗反应的影响,以及针对 PIDS 的复杂性开发创新的干预措施。本研究旨在对这些因素进行全面概述,并讨论其潜在的病理生物学关系。
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来源期刊
Pain and Therapy
Pain and Therapy CLINICAL NEUROLOGY-
CiteScore
6.60
自引率
5.00%
发文量
110
审稿时长
6 weeks
期刊介绍: Pain and Therapy is an international, open access, peer-reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of pain therapies and pain-related devices. Studies relating to diagnosis, pharmacoeconomics, public health, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to, acute pain, cancer pain, chronic pain, headache and migraine, neuropathic pain, opioids, palliative care and pain ethics, peri- and post-operative pain as well as rheumatic pain and fibromyalgia. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports, trial protocols, short communications such as commentaries and editorials, and letters. The journal is read by a global audience and receives submissions from around the world. Pain and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.
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