Interhemispheric functional in age-related macular degeneration patient: a resting-state functional MRI study.

IF 1.6 4区 医学 Q4 NEUROSCIENCES Neuroreport Pub Date : 2024-07-01 Epub Date: 2024-05-15 DOI:10.1097/WNR.0000000000002045
Yi-Jing Jiang, Ping-Hong Lai, Xin Huang
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Abstract

Age-related macular degeneration (AMD) is a prevalent disease leading to severe visual impairment in the elderly population. Despite this, the pathogenesis of AMD remains largely unexplored. The application of resting-state functional MRI (rs-fMRI) allows for the detection of coherent intrinsic brain activities along with the interactions taking place between the two hemispheres. In the frame of our study, we utilize voxel-mirrored homotopic connectivity (VMHC) as an rs-fMRI method to carry out a comparative analysis of functional homotopy between the two hemispheres with the aim of further understanding the pathogenesis of AMD patients. In our study, we utilized the VMHC method to explore levels of brain activity in individuals diagnosed with AMD, planning to investigate potential links with their clinical characteristics. We extended our invitation to 20 AMD patients and 20 healthy controls from Jiangxi Provincial People's Hospital to participate in this research. rs-fMRIs were captured for each participant, and associated neural activity levels were examined using the VMHC method. Remarkably, our comparative examination with the healthy control group revealed significantly reduced VMHC in the cuneus, superior occipital lobe, precentral gyrus, and superior parietal lobule in the patient cohort. Utilizing the VMHC method allows us to identify discrepancies in the visual pathways of AMD patients compared with standard controls, potentially explaining the common challenges among AMD patients with object recognition, face recognition, and reading.

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老年性黄斑变性患者的半球间功能:静息态功能磁共振成像研究。
老年性黄斑变性(AMD)是一种导致老年人群严重视力损伤的常见疾病。尽管如此,老年黄斑变性的发病机理在很大程度上仍未得到探索。应用静息态功能磁共振成像(rs-fMRI)可以检测大脑固有的连贯活动以及两个半球之间的相互作用。在我们的研究框架中,我们利用体素映射同位连接(VMHC)作为一种rs-fMRI方法,对两个半球之间的功能同位性进行比较分析,旨在进一步了解AMD患者的发病机制。在我们的研究中,我们利用 VMHC 方法探讨了确诊为 AMD 患者的大脑活动水平,并计划研究其与临床特征之间的潜在联系。我们邀请了江西省人民医院的20名AMD患者和20名健康对照者参与这项研究。我们为每位参与者采集了rs-fMRI,并使用VMHC方法检测了相关的神经活动水平。值得注意的是,我们与健康对照组的对比检查发现,患者群中楔叶、枕叶上部、中央前回和顶叶上部的 VMHC 明显减少。利用VMHC方法,我们可以发现AMD患者的视觉通路与标准对照组的差异,这可能解释了AMD患者在物体识别、人脸识别和阅读方面面临的共同挑战。
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来源期刊
Neuroreport
Neuroreport 医学-神经科学
CiteScore
3.20
自引率
0.00%
发文量
150
审稿时长
1 months
期刊介绍: NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.
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