A case report of pediatric-onset MS associated uveitis.

Zahra Mahdizad, Mohammad Zarei, Hanieh Fakhredin, Reza Samiee, Hora Heidari, Nazanin Ebrahimiadib
{"title":"A case report of pediatric-onset MS associated uveitis.","authors":"Zahra Mahdizad, Mohammad Zarei, Hanieh Fakhredin, Reza Samiee, Hora Heidari, Nazanin Ebrahimiadib","doi":"10.1186/s12348-024-00405-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>To report a case of Pediatric-onset MS associated uveitis managed with local and systemic medications.</p><p><strong>Case presentation: </strong>An 11-year-old boy who was diagnosed with Pediatric-onset MS (POMS) with the first presentation of left optic neuritis in another center, was referred to our clinic with the complaint of non-improved vision in the left eye despite receiving IV 5gr methylprednisolone. After the ophthalmologic examinations, the patient was diagnosed as bilateral POMS-associated intermediate uveitis, and local treatment with corticosteroid was administered to both eyes. He was continued on systemic therapy such as Rituximab and five sessions of plasmapheresis. After four months, the patient's vision improved from FC at 50cm to 9/10 in the left eye. The intensity of intraocular inflammation decreased in both eyes. In fluorescein angiography findings, the optic disc, as well as vascular leakage, subsided bilaterally.</p><p><strong>Conclusion: </strong>Despite its rarity, POMS-associated uveitis presents a considerable challenge that necessitates the collaborative efforts of neurologists and ophthalmologists to achieve the most effective treatment outcomes.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"14 1","pages":"21"},"PeriodicalIF":2.9000,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136925/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Ophthalmic Inflammation and Infection","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s12348-024-00405-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: To report a case of Pediatric-onset MS associated uveitis managed with local and systemic medications.

Case presentation: An 11-year-old boy who was diagnosed with Pediatric-onset MS (POMS) with the first presentation of left optic neuritis in another center, was referred to our clinic with the complaint of non-improved vision in the left eye despite receiving IV 5gr methylprednisolone. After the ophthalmologic examinations, the patient was diagnosed as bilateral POMS-associated intermediate uveitis, and local treatment with corticosteroid was administered to both eyes. He was continued on systemic therapy such as Rituximab and five sessions of plasmapheresis. After four months, the patient's vision improved from FC at 50cm to 9/10 in the left eye. The intensity of intraocular inflammation decreased in both eyes. In fluorescein angiography findings, the optic disc, as well as vascular leakage, subsided bilaterally.

Conclusion: Despite its rarity, POMS-associated uveitis presents a considerable challenge that necessitates the collaborative efforts of neurologists and ophthalmologists to achieve the most effective treatment outcomes.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
儿科多发性硬化症相关葡萄膜炎病例报告。
背景:报告一例使用局部和全身药物治疗的小儿多发性硬化症相关葡萄膜炎病例:一名11岁的男孩在另一家医院被诊断为小儿多发性硬化症(POMS),首次表现为左侧视神经炎,后转诊至我院,主诉为左眼视力无改善,尽管已静脉滴注5gr甲基强的松龙。眼科检查后,患者被诊断为双侧 POMS 相关性中葡萄膜炎,双眼均接受了皮质类固醇局部治疗。他继续接受利妥昔单抗等全身治疗,并进行了五次浆细胞分离术。四个月后,患者左眼的视力从 50 厘米处的 FC 提高到 9/10。双眼的眼内炎症强度均有所下降。荧光素血管造影结果显示,双侧视盘和血管渗漏均已消退:尽管POMS相关葡萄膜炎非常罕见,但它仍是一个巨大的挑战,需要神经科医生和眼科医生通力合作,才能取得最有效的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
3.80
自引率
3.40%
发文量
39
审稿时长
13 weeks
期刊最新文献
Long-term effects of tocilizumab on retinal and choroidal inflammation in Birdshot uveitis. "Infectious uveitis: a comprehensive systematic review of emerging trends and molecular pathogenesis using network analysis". Isolated hydatid cyst in the medial rectus muscle: unveiling a rare orbital occurrence. Ocular loaiasis in France: the first case report from Brittany. Effect of intravitreal injection of anti-interleukin (IL)-6 antibody in experimental autoimmune uveitis in mice.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1