Placenta-targeted Treatment Strategies for Preeclampsia and Fetal Growth Restriction: An Opportunity and Major Challenge.

IF 4.5 3区医学 Q2 CELL & TISSUE ENGINEERING Stem Cell Reviews and Reports Pub Date : 2024-08-01 Epub Date: 2024-05-30 DOI:10.1007/s12015-024-10739-x

Jianjian Cui, Zejun Yang, Ruilin Ma, Wencong He, Hui Tao, Ya'nan Li, Yin Zhao

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Abstract

The placenta plays a crucial role in maintaining normal pregnancy. The failure of spiral artery remodeling (SAR) is a key factor leading to placental ischemia and poor perfusion which is strongly associated with obstetric diseases, including preeclampsia (PE) and fetal growth restriction (FGR). Existing interventions for PE and FGR are limited and termination of pregnancy is inevitable when the maternal or fetus condition deteriorates. Considering the safety of the mother and fetus, treatments that may penetrate the placental barrier and harm the fetus are not accepted. Developing targeted treatment strategies for these conditions is urgent and necessary. With the proven efficacy of targeted therapy in treating conditions such as endometrial cancer and trophoblastic tumors, research on placental dysfunction continues to deepen. This article reviews the studies on placenta-targeted treatment and drug delivery strategies, summarizes the characteristics proposes corresponding improvement measures in targeted treatment, provides solutions for existing problems, and makes suggestions for future studies.

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针对子痫前期和胎儿生长受限的胎盘靶向治疗策略：机遇与挑战并存

胎盘在维持正常妊娠中起着至关重要的作用。螺旋动脉重塑（SAR）失败是导致胎盘缺血和灌注不良的关键因素，而这与产科疾病（包括子痫前期（PE）和胎儿生长受限（FGR））密切相关。现有的针对子痫前期和胎儿生长受限的干预措施非常有限，当母体或胎儿状况恶化时，终止妊娠是不可避免的。考虑到母亲和胎儿的安全，不接受可能穿透胎盘屏障并伤害胎儿的治疗方法。针对这些病症制定靶向治疗策略是非常迫切和必要的。随着靶向治疗在治疗子宫内膜癌和滋养细胞肿瘤等疾病方面的疗效得到证实，有关胎盘功能障碍的研究也在不断深入。本文综述了胎盘靶向治疗及给药策略的研究，总结了靶向治疗的特点提出了相应的改进措施，针对存在的问题提出了解决方案，并对今后的研究提出了建议。

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来源期刊

Stem Cell Reviews and Reports 医学-细胞生物学

CiteScore

9.30

自引率

4.20%

发文量

审稿时长

3 months

期刊介绍： The purpose of Stem Cell Reviews and Reports is to cover contemporary and emerging areas in stem cell research and regenerative medicine. The journal will consider for publication: i) solicited or unsolicited reviews of topical areas of stem cell biology that highlight, critique and synthesize recent important findings in the field. ii) full length and short reports presenting original experimental work. iii) translational stem cell studies describing results of clinical trials using stem cells as therapeutics. iv) papers focused on diseases of stem cells. v) hypothesis and commentary articles as opinion-based pieces in which authors can propose a new theory, interpretation of a controversial area in stem cell biology, or a stem cell biology question or paradigm. These articles contain more speculation than reviews, but they should be based on solid rationale. vi) protocols as peer-reviewed procedures that provide step-by-step descriptions, outlined in sufficient detail, so that both experts and novices can apply them to their own research. vii) letters to the editor and correspondence. In order to facilitate this exchange of scientific information and exciting novel ideas, the journal has created five thematic sections, focusing on: i) the role of adult stem cells in tissue regeneration; ii) progress in research on induced pluripotent stem cells, embryonic stem cells and mechanism governing embryogenesis and tissue development; iii) the role of microenvironment and extracellular microvesicles in directing the fate of stem cells; iv) mechanisms of stem cell trafficking, stem cell mobilization and homing with special emphasis on hematopoiesis; v) the role of stem cells in aging processes and cancerogenesis.